SYNTHESIS AND SPECTREAL CHARACTERIZATION OF PYRAZOLINE DERIVATIVES FROM CHALCONE DERIVATIVES
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 12
Abstract
The present research work describes the synthesis of new pyrazoline compounds and Chalcone derivatives. Synthesis of chalcones (1-9) were achived by condensation of diacetyl with substituted benzaldehyde in ethanolic sodium hydroxide (50%). The later compounds reacted with hydrazine hydrate (80%) in glacial acetic acid to yield 1,1'-(aryl -4,5-dihydro-1H-pyrazole-1,3-diyl)bis(ethan-1-one) (10-17). The characterization of the resulting products were confirmed by melting points, UV-Visible, FTIR, 1HMNR, 13C-NMR and Mass. (for some of them) spectral data.
Authors and Affiliations
Eman M. Hassan
Keywords
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