SYNTHESIS AND SPECTROPHOTOMETRIC STUDIES OF SOME NEW COUMARINDERIVATIVES.

Journal Title: International Journal of Advanced Research (IJAR) - Year 2018, Vol 6, Issue 11

Abstract

The current study was designed to investigate the reactivity of 3-acetyl-6-bromocoumarintowards a variety of electrophilic and nucleophilic reagents such as aromatic aldehydes to give 3-cinnamoyl coumarins 2a,b. The reaction of2b with guanidine hydrochloride gave 6-bromo-3-(substituted pyrimidine)coumarin-3-yl 3. Other6-bromo-3-(substituted pyrimidine) coumarin-3-ylderivatives 5a and 5b were synthesized from treatment of 1 with thiosemicarbazide then treating the product 4 with active methylene compounds namely diethyl malonate and/or ethyl acetoacetate. Treating 4 with phenacyl bromide yielded the corresponding phenyl thiazole derivative 7. Alkylation of 4 with acetic anhydride and/or benzoyl chloride yielded the corresponding diacetyl-and/or di benzoyl derivatives6a,b. The reaction of 4 with ethyl chloroacetate and/or chloro acetic acid in different media yielded two isomers 8a and 8b. The reaction of 1 with nitriles such as malononitrile and/or ethyl cyanoacetatefollowed by treatment with sulfur gave corresponding coumarin -3-y?thiophene derivatives 10a,b. The structures of the newly synthesized derivatives were elucidated by means of microanalysis, IR, 1H-NMR, 13C-NMR and MS measurments. The UV-Vis absorption spectra of the various newly 3-substituted-6-bromo coumarin derivatives 1-10were investigated in expectation of the shift to the longer wavelength region by the extension of the conjugated system. The absorption properties of the prepared compounds were investigated spectrophotometrically by dissolving in chloroform in the range 200-800 nm using 1cm quartz cells, showed good UV absorption properties and were discussed from the view point of the intermolecular charge transfer (ICT) between push- and pull- substituents.

Authors and Affiliations

Fekriam. a. Soliman, zeinab h. Ismail, nahed f. Abd el- ghaffar, nadiat. a. Dawood, shaimaah. Abd el monem.

Keywords

Related Articles

LOBULATIONS OF THE FOETAL KIDNEY.

Introduction: The knowledge of the lobulation pattern of foetal and adult kidneys is necessary for determining the normal anatomy of kidneys. Aim: To study the foetal and adult kidneys for lobulations. Method: 100 dissec...

ASSESSMENT OF KNOWLEDGE, AWARENESS ON GLAUCOMA AMONG GLAUCOMA PATIENTS & ITS IMPACT ON DAILY LIFE.

Aim: To assess the knowledge, awareness on glaucoma and its impact on the quality of life of patients with glaucoma. Materials and method: A questionnaire was delivered to patients willing to take part,and have a regular...

ARTIFICIAL INTELLIGENCE IN DENTISTRY: CURRENT CONCEPTS AND A PEEP INTO THE FUTURE.

The last decade has marked the evolution of artificial intelligence which has been ushered in with tremendous hype and enthusiasm and dentistry is no exception. The tremendous amount of patient data requires intelligent...

EVALUATION OF STRESS AND DEFORMATION ON PROSTHETIC IMPLANTS DURING MINI-PLATE ASSISTED CANINE AND EN-MASSE RETRACTION IN LINGUAL ORTHODONTICS: A FINITE ELEMENT IN SILICO STUDY.

Lingual appliances marked a great leap forward in aesthetic orthodontics. Due to their distinct biomechanics compared to conventional orthodontics, special care must be taken in their application. As mini-plate and impla...

SATISFACTION OF PATIENTS ADMITTED TO AL.IMAMAIN AL.KADHIMAIN TEACHING HOSPITAL WITH QUALITY OF HEALTH CARE SERVICES.

Introduction: In the modern open and multiple choices world, provision of high quality services and improvement of patients\' conviction are becoming a critical objective to avoid patients\' transfer to another health ca...

Download PDF file
  • EP ID EP424121
  • DOI 10.21474/IJAR01/8079
  • Views 65
  • Downloads 0

How To Cite

Fekriam. a. Soliman, zeinab h. Ismail, nahed f. Abd el- ghaffar, nadiat. a. Dawood, shaimaah. Abd el monem. (2018). SYNTHESIS AND SPECTROPHOTOMETRIC STUDIES OF SOME NEW COUMARINDERIVATIVES.. International Journal of Advanced Research (IJAR), 6(11), 928-952. https://europub.co.uk/articles/-A-424121