Synthesis, antiviral and cytotoxicity activities of N-Sulphonamidomethyl benztriazole derivatives
Journal Title: International Journal of Pharmacy and Analytical Research - Year 2013, Vol 2, Issue 1
Abstract
A series of novel N-sulphonamido methyl benztriazole derivatives had been synthesized by combining benztriazole, formaldehyde and sulphonamides. Structure of synthesized compounds was elucidated by spectral analysis. Synthesized compounds were evaluated for in-vitro antiviral activity against HIV, HSV and Vaccinia viruses in cell culture. N-Sulphonamido methyl benzotriazole (BT-SN) inhibits Herpes Simplex Virus (HSV) -2 and Vaccinia virus at 34 µg/ml, respectively. HSV-1 at the concentration of 45 µg/ml. The minimum cytotoxic concentration was found to be more than 100µg/ml. So these compounds are suitable for designing newer derivatives and molecular modifications in them may help in optimizing antiviral activity.
Authors and Affiliations
Selvam P
Keywords
Related Articles
- EP ID EP648976
- DOI -
- Views 64
- Downloads 1
Fabrication and evaluation of a stable flurbiprofen hydrogel
The purpose of the study was to prepare a stable 6% Flurbiprofen hydrogel. Oral Flurbiprofen generates several side effects; hence hydrogel was prepared to reduce these side effects in the present study. Gastrointestinal...
RP-HPLC Method Development and Validation for the Simultaneous Estimation of Atenolol and Indapamide in Pharmaceutical Tablet Dosage Form
A simple reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed and validated for simultaneous determination of ATENOLOL and INDAPAMIDE in pharmaceutical tablet dosage form. Chromatogr...
RP-HPLC Assay Method Validation for the estimation of new Anti-retroviral drug Lamivudine in Bulk and Tablet dosage form
A Reverse phase HPLC method was developed for estimation of the Lamivudine in bulk and tablet formulation by using ODS column (250mm×4.6mm, 5µm) and Acetate buffer: acetonitrile (50:50) as mobile phase, at a flow rate of...
Consumer’s Perception Regarding Pharmaceutical Product Packaging: A Survey of Pakistan
The packaging of the pharmaceutical product plays an important role to maintain the product stability and an increase in sales which ultimately increase in profit margin of any organization. The packaging continuously pr...
Synthesis and Pharmacological evaluation of new Benzoxozole Derivatives
Benzoxazoles1 are usually prepared by heating 2-Aminophenol with formic acids in the presence of Boric acid under reflux. Condensation of these two substances under milder conditions. Being a heterocyclic compound, benzo...