Synthesis, characterization and antibacterial activity of some N-alkyl benzimidazol piperazine fluoroquinolines
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 5
Abstract
A series of N-alkyl benzimidazol piperazine fluoroquinolines with remarkable improvement in antimicrobial activity as compared to the moxifloxacin were synthesized and characterized by 1HNMR, 13C NMR, IR, Mass and elemental analysis. These derivatives were evaluated for their invitro activity against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae. The results showed that all the synthesized derivatives of novel fluoroquinolines possess antimicrobial activity. However, compound derivatives IV and V3 have antibacterial activities against Pseudomonas, Klebsiella and Staphylococcus epidermidis. Among all these derivatives, compound V3 exhibit potent inhibitory activity with MIC of 19 µg/mL.
Authors and Affiliations
Prita S. Borkar
Keywords
Related Articles
- EP ID EP514781
- DOI -
- Views 38
- Downloads 0
To study the hip circumference to neck circumference ratio and neck circumference as a risk factor for coronary artery disease
nd beyond visceral abdominal fat. Anatomically, upper-body subcutaneous fat is a unique fat depot located in a separate compartment compared with visceral adipose tissue. Aims and Objective: to determine the reliability...
A Rare and Fatal Complication of Diabetes Mellitus
Emphysematous pyelonephritis (EPN) is an acute suppurative infection of the kidney. It is an uncommon infection, occurs mostly in patients with diabetes and a predilection for females. It has a high fatality rate; theref...
Raised Red Cell Distribution Width as a Risk Assessment Prognostic Tool For Post Myocardial Infarction Patients
Objectives & Aims: The evaluation and identify new prognostic markers suggested in recent studies for coronary heart disease ,raised red blood cell distribution width (RDW) has been found to be associated with poor progn...
A Review of Severe Acute Maternal Morbidity (SAMM) through “Three Delays Model”
Introduction: Every mother should live beyond pregnancy and childbirth. Why do women die, what could have been done, where did we missed out answers to these and many other questions related to maternal mortality are hid...
Ultrasound grading of fatty liver and association with obesity
Introduction: The most common incidental finding in an ultrasound abdomen scan is fatty liver. The significance of this finding is a curiosity for the radiologist and the clinician as there has been lots of study with eq...