Synthesis, Characterization and Antimicrobial screening of some new bipyridinyl substituted coumarin
Journal Title: International Journal of Engineering and Science Invention - Year 2018, Vol 7, Issue 7
Abstract
The synthesis of various 7-methoxy-4-methyl-8-(4'-aryl-2',2''-bipyridin-6'-yl)coumarins (5a-c); 7- methoxy-4-methyl-8-(4'-aryl-2',3''-bipyridin-6'-yl)coumarins (6a-c) and 7-methoxy-4-methyl-8-(4'-aryl-2',4''- bipyridin-6'-yl) coumarins (7a-c) has been carried out by the reaction of 4-methyl-7-methoxy-8-coumarinoyl methyl pyridinium bromide salt (1) with various 3-aryl-1-(pyridin-2-yl)prop-2-en-1-ones (2a-c), 3-aryl-1- (pyridin-3-yl)prop-2-en-1-ones (3a-c) and 3-aryl-1-(pyridin-4-yl)prop-2-en-1-ones (4a-c) respectively in the presence of ammonium acetate in refluxing acetic acid (Scheme 1)under Krohnke’s reaction condition. The required chalcones 3-aryl-1-(pyridin-2-yl)-prop-2-ene-1-ones (2a-c), 3-aryl-1-(pyridin-3-yl)-prop-2-ene-1-ones (3a-c) and 3-aryl-1-(pyridin-4-yl)-prop-2-ene-1-ones (4a-c) were prepared by the reaction of respective 2- acetyl pyridine, 3-acetyl pyridine and 4-acetyl pyridine with various p-substituted benzaldehydes in the presence of sodium hydroxide in ethanol.The synthesis of compounds 7-methoxy-4-methyl-8-(6'-aryl-4',2''-bipyridin-2'- yl)coumarins (11a-c); 7-methoxy-4-methyl-8-(6'-aryl-4',3''-bipyridin-2'-yl)coumarins (12a-c) and 7-methoxy-4- methyl-8-(6'-aryl-4',4''-bipyridin-2'-yl)coumarins (13a-c) has been carried out by the reaction of 4-methyl-7- methoxy-8-coumarinoyl methyl pyridinium bromide salt (1) with various 1-aryl-3-(pyridin-2-yl)prop-2-en-1- ones (8a-c),1-aryl-3-(pyridin-3-yl)prop-2-en-1-ones (9a-c) and 1-aryl-3-(pyridin-4-yl)prop-2-en-1-ones (10ac)respectively in the presence of ammonium acetate in refluxing acetic acid under Krohnke’s reaction condition.(Scheme 3). The required chalcones(8a-c),(9a-c) and (10a-c) were prepared by the reaction of various p-substituted acetophenones with 2-formyl pyridine, 3-formyl pyridine and 4-formyl pyridine respectively in the presence of sodium hydroxide in ethanol. The structures of all the compounds synthesized, have been supported by analytical and spectral data. All the synthesized compounds were screened for their antimicrobial activity.
Authors and Affiliations
Jigar Patel
Keywords
Related Articles
- EP ID EP397496
- DOI -
- Views 64
- Downloads 0
Water Gas Shift Reaction Characteristics Using Syngas from Waste Gasification
The characteristics of a high temperature water gas shift reaction over a commercial Fe-based catalyst using syngas from waste gasification were investigated using lab equipment tests and found to be feasible for produci...
Compressive Strength and Thickening Time of Cement in Oil Well
Proper slurry design is critical to the success of a cementing job. The best method to obtain a good slurry design with desired compressive strength is by laboratory experiments which involve experimenting different form...
Information Pre-Rendering For Categorization Using Waikato Environment For Knowledge Analysis
Pattern measurements through incalculable examinations delineate that there is an exponential development of information shape terabytes to petabytes and past on the planet. This reality brings into point of view the evi...
A Brief Historical Overview Of the Gaussian Curve: From Abraham De Moivre to Johann Carl Friedrich Gauss
If there were only one law of probability to be known, this would be the Gaussian distribution. Faced with this uneasiness, this article intends to discuss about this distribution associated with its graph called the Gau...
Review Paper on Implementation of 5 S in Different Organizations
This Paper Describes The Methods And Techniques Of 5s Which Are Used To Increase The Efficiency Of All Processes In The Industry. The Main Goal Is To Reduce The Losses In The Industry And The Implementation Of The 5s Sys...