Synthesis, Characterization and Biological Activity Evaluation of Some Divalent Tranzitional Metals Complexes with N-p-Nitrobenzoyl-D-L- Phenylglycine
Journal Title: BULETINUL INSTITUTULUI POLITEHNIC DIN IASI, CHIMIE SI INGINERIE CHIMICA - Year 2018, Vol 64, Issue 3
Abstract
This paper presents the synthesis of some Mn(II), Co(II), Ni(II) and Cu(II) complexes with N-p-nitrobenzoyl-D-L-phenylglycine (NBPG) as ligand. The characterization of the above mentioned synthesised compounds involved the structure determination by elemental analysis, FTIR spectroscopy, X-ray diffraction (XRD) and electron spin resonance (ESR). Experimental data sustain that all Mn, Co, Ni and Cu derivatives of N-p-nitrobenzoyl-D-L-phenylglycine present a crystalline structure framed orthorhombic system and are thermally stable up to temperatures above 100°C. The results of the toxicity tests on mice indicated that the lowest value of the lethal dose is displayed by the Cu complex compound. The antibacterial and antifungal activities investigations revealed that the Co[(L)2(H2O)2] compound displays the best antibacterial properties while the Cu[(L)2(H2O)2] compound presents the best antifungal properties.
Authors and Affiliations
CĂTĂLINA ROŞCA, VALERIU ŞUNEL, MIHAELA CREŢU, MARIANA DIACONU, DANIEL MARECI, CARMEN MÎŢĂ, CORNEL STAN, Gabriela Antoaneta Apostolescu
Keywords
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