SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SUBSTITUTED 1,3,4-OXADIAZOLE DERIVATIVE: DERIVED FROM CIPROFLOXACIN
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 9
Abstract
Objective: The purpose of this research is synthesized and evaluates different derivatives of oxadiazole. Methods: A novel series of substituted 1,3,4-oxadiazole derivative were synthesized by condensing different amine with 1-cyclopropyl-6-fluoro-7- (piperazin-1-yl)-3-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)quinolin-4(1H)-one (III) in the presence of formaldehyde. The structure of these novel synthesized compounds was characterized on the bases of physicochemical and spectral analysis. The title compounds (IVa-h) were screened for antibacterial activity by disc diffusion method. Results: Substituted 1,3,4-oxadiazole derivative was synthesized, characterized, and evaluated for antibacterial activity. Compounds IVa, IVd, IVe, IVf, and IV h showed enhance activities then ciprofloxacin against all Gram-positive and Gram-negative organisms. Compound IVe showed the highest activity against Staphylococcus aureus and compound IV showed the highest activity against Escherichia coli. Conclusion: The present study demonstrates the synthesis and characterization of 1,3,4-oxadiazole derivatives derived from ciprofloxacin. These compounds were evaluated for antibacterial activity against different Gram-positive and Gram-negative organism. In some cases, antibacterial activity is found to be enhanced as compared to standard drug ciprofloxacin.
Authors and Affiliations
ANUJ SINGHAI , GUPTA MK
TO STUDY THE ULCEROPROTECTIVE EFFECT OF LEAVES OF MORINGA OLEIFERA ON EXPERIMENTALLY INDUCED INFLAMMATORY BOWEL DISEASE ON ANIMAL MODELS
Objective: The present study was carried out to evaluate the ulceroprotective effect of ethanolic extract of leaves of Moringa oleifera (EEMO) on experimentally induced inflammatory bowel disease (IBD) on Albino (Wistar...
STUDY ON ANTIBACTERIAL EFFECTS OF SEVERAL VIETNAMESE MEDICINE PLANTS AND THEIR RELATIONSHIPS WITH POLYPHENOL CONTENTS
Objective: Our study evaluated the inhibitory effects of 13 plant materials on bacterial growth, so as to explain their traditional uses in bacterial infections. In addition, the correlation between antibacterial effects...
QUANTITATIVE ANALYSIS OF TOTAL PHENOLS AND FLAVONOIDS IN IN VIVO AND IN VITRO SAMPLES OF OROXYLUM INDICUM (L.) VENT.
 Objective: This paper presents flavonoids and phenol content of methanolic extract of in vivo and in vitro sample of Oroxylum indicum (L.) Vent. animportant medicinal plant. Selected plant contains number of phytochemi...
FORMULATION, IN-VITRO&IN-VIVO EVALUATION OF NANOEMULSION GEL FOR TRANSDERMAL DRUG DELIVERY OF NIMODIPINE
 Objective: The objective of this study was to develop and evaluate the potential of nanoemulsion (NE) as drug carrier system for transdermal deliveryof nimodipine.Methods: Nimodipine NE was developed through titration...
PHARMACOLOGICAL TREATMENT OF OSTEOPOROSIS IN PATIENTS WITH CORONARY HEART DISEASE COMPLICATED BY CHRONIC HEART FAILURE
Objective: Chronic heart failure (CHF) is a chronic multisystem disorder associated with a myriad of metabolic disturbances. Moreover, CHF may adversely affect bone metabolism and induce a severe bone loss, increasing su...