Synthesis, Characterization And Biological Studies Of N'',N'''- Bis[(E)-(4-Fluorophenyl) Methylidene] Thiocarbonohydrazide
Journal Title: International Journal of Engineering and Science Invention - Year 2017, Vol 6, Issue 9
Abstract
The N'',N'''-bis[(E)-(4-fluorophenyl)methylidene] thiocarbonohydrazide viz. bis-(4-fluoro PM) TCH which is new symmetric derivative of thiocarbohydrazide has been synthesized by reacting thiocarbohydrazide with double equivalent amount p- fluoro benzaldehyde in ethanol medium at refluxing conditions. Elemental and spectral (Uv-visible, IR and NMR) analyses carried out for characterization of bis-(4-fluoroPM) TCH. This new derivative of thiocarbohydrazide was tested for the evaluation of antibacterial activity against Staphylococcus aureus and Escherichia coli and antifungal activity against Aspergillus niger and Rhizopus sps. This compound is biologically active in very low concentration.
Authors and Affiliations
Rekha Nalawade, Avinash Nalawade, Rajendra Shejwal, Mansing Anuse
Keywords
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