SYNTHESIS, CHARACTERIZATION AND EVALUATION OF MICROBIAL ACTIVITY OF SOME HETEROCYCLIC COMPOUNDS CONTAINING BENZOTHIAZOLE MOIETIES
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 5
Abstract
New derivatives of five member heterocyclic compounds containing benzothiazole rings are reported. These compounds have been characterized by elemental analysis, FT-IR and 1H NMR spectroscopy, 13 C NMR and Mass spectral analysis. This study was designed to show the microbial activity of substituted benzothiazoles. The compounds were screened for antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis in nutrient agar medium, and for antifungal activity against Aspergillus niger and Candida albicans in Sabouraud,s dextrose agar medium.The results show that the derivatives containing benzothiazole moiety are more active.
Authors and Affiliations
Rekha. S*| Dept. of Pharmaceutical chemistry, T. John College of Pharmacy, Bangalore, Karnataka, India-560042., Prateek bisht| Dept. of Pharmaceutical chemistry, T. John College of Pharmacy, Bangalore, Karnataka, India-560042., Chandrashekhara. S| Dept. of Pharmaceutics, M.M College of Pharmacy, Belgaum, Karnataka, India-590016., Shantharam. U| Dept. of Pharmaceutical chemistry, Government College of Pharmacy, Bangalore, Karnataka, India-560027., Vineeth chandy| Dept. of Pharmaceutical chemistry, T. John College of Pharmacy, Bangalore, Karnataka, India-560042., Prof. Satyanand Tyagi| President & Founder, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), New Delhi, India- 110074.
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