SYNTHESIS, CHARACTERIZATION AND EVALUATION OF MICROBIAL ACTIVITY OF SOME HETEROCYCLIC COMPOUNDS CONTAINING BENZOTHIAZOLE MOIETIES
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 5
Abstract
New derivatives of five member heterocyclic compounds containing benzothiazole rings are reported. These compounds have been characterized by elemental analysis, FT-IR and 1H NMR spectroscopy, 13 C NMR and Mass spectral analysis. This study was designed to show the microbial activity of substituted benzothiazoles. The compounds were screened for antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis in nutrient agar medium, and for antifungal activity against Aspergillus niger and Candida albicans in Sabouraud,s dextrose agar medium.The results show that the derivatives containing benzothiazole moiety are more active.
Authors and Affiliations
Rekha. S*| Dept. of Pharmaceutical chemistry, T. John College of Pharmacy, Bangalore, Karnataka, India-560042., Prateek bisht| Dept. of Pharmaceutical chemistry, T. John College of Pharmacy, Bangalore, Karnataka, India-560042., Chandrashekhara. S| Dept. of Pharmaceutics, M.M College of Pharmacy, Belgaum, Karnataka, India-590016., Shantharam. U| Dept. of Pharmaceutical chemistry, Government College of Pharmacy, Bangalore, Karnataka, India-560027., Vineeth chandy| Dept. of Pharmaceutical chemistry, T. John College of Pharmacy, Bangalore, Karnataka, India-560042., Prof. Satyanand Tyagi| President & Founder, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), New Delhi, India- 110074.
Keywords
Related Articles
- EP ID EP1384
- DOI -
- Views 472
- Downloads 33
TREATMENT AND MANAGEMENT OF DIABETES WITH STEM CELL THERAPY: A NEWER SCIENTIFIC APPRAOCH
Diabetes is usually a lifelong (chronic) disease in which there are high levels of sugar in the blood. Diabetes, often referred to by doctors as diabetes mellitus, describes a group of metabolic diseases in which the per...
Knowledge, attitude and practice of ADR reporting among clinical residents: A rural medical college survey
Introduction: Pharmacovigilance practices have persistently suffered from under-reporting of ADRs by the clinicians. The present study was done to assess the knowledge, attitude and practices of clinical residents toward...
Life threatening ventilatory obstruction due to a foreign body in a new sealed endotracheal tube
In the current days of high tech equipment and well defined safety regulations, technical failures are less likely to occur. Still many manufacturing and packaging errors are encountered in anaesthetic practice which go...
Formulation and evaluation of aspirin, paracitamol and serratiopeptidase tablet conventional dosage form an overview
The present studies are based on the single nsaid drug dosage form or on the combination of nsaid along with analgesic. Some drug combination also provides pain relief with proteolytic enzyme that prevents the GI bleedin...
Vitilego Cure by Homoeopathy
Vitiligo known as leucoderma is a relatively common skin disorder, in which white spots or patches appear on the skin. These spots are caused by destruction or weakening of the pigment cells in those areas, resulting in...