Synthesis, characterization and evaluation of new benzimidazole derivatives
Journal Title: World Journal of Pharmaceutical Sciences - Year 2016, Vol 4, Issue 10
Abstract
A series of new benzimidazole derivatives have been synthesized by simple condensation (Schiff reaction) reaction between benzimidazole derivatives and substituted aromatic aldehydes. All these compounds were characterized by FT-IR, 1HNMR, Mass spectral and TLC analysis thus compounds were screened for antibacterial and antifungal activities respectively. The antibacterial activities were compared with the standard drug such as norfloxacin and antifungal activities were compared with fluconazole. Among synthesized compounds, the compound with 4 – chloro IV b on the aromatic ring possessing good antibacterial activity, however lower than standard norfloxacin and the compound with 4 – dimethyl amine group IV d showed better antifungal activity; almost similar to that of standard, fluconazole thus they could be promising candidates for novel drugs.
Authors and Affiliations
Sandyarani Tatipamula
Keywords
Related Articles
- EP ID EP202787
- DOI -
- Views 57
- Downloads 0
Management of chronic non-healing wound by Hirudotherapy
A chronic wound is that wound which does not heal in an regular set of stages and in a expected amount of time or wounds that do not heal within three months are often considered chronic.[1] Chronic wounds often remain i...
Characterization of prescription and OTC formulations of vidarabine cream
The aim of this study, to assess the uniformity of content, viscosity, spreadability, near-infrared absorption spectroscopy and water content of vidarabine cream (Ara-A: bland name, Ara-B: generic and Ara-C: Over the Cou...
Antiplasmodial Activity of Ethanol Extract and Fractions of Nauclea Latifolia Smith (Rubiacea) Roots
Malaria is a parasitic disease that is endemic in Nigeria with one of the greatest challenges being the development of resistance by Plasmodium falciparum against chloroquine and Artemisinin combination therapy (ACT). Si...
Knowledge, attitude and practices of type II diabetes mellitus patients in a tertiary care teaching institute of central India
Introduction: Increasing knowledge of diabetes mellitus (DM) patients regarding life-style modification can help in reducing morbidity and mortality in them. Objectives: To determine the knowledge, attitude, practices (K...
Knowledge among Children about Nutritive Value of Food and Diet
Present study is very important because it is about two important things the one is food and nutrition, that is basic need and the second one is children, they are future of any nation. The composition of a diet vastly d...