Synthesis, Characterization, antimicrobial, anticancer and antihemolytic activity of Co (II), Ni (II) and Cu (II) complexes with 2– methoxy-6-(3-iminoquinolinyl methyl) phenol
Journal Title: International Journal of Engineering and Science Invention - Year 2018, Vol 7, Issue 6
Abstract
A Schiff base ligand was synthesized by condensation of o-vanillin with 3-aminoquinoline in 1:1 molar ratio. The Schiff base metal complexes of Co (II), Ni (II) and Cu (II) were prepared using the metal salt and ligand in 1:2 ratio. The metal complexes were characterized byusing elemental analysis, molar conductance, magnetic susceptibility, UV-Visible, and IR spectra. They were also characterized bytheir thermo gravimetric analysis. The compositions of the Schiff base ligand and the metal complexes were established by elemental analysis which indicated a metal: ligand ratio of 1:2.Magnetic, thermal and spectral studies indicated that ligand behaved as bidentate coordinating through phenolic oxygen and azomethine nitrogen and formed octahedral metal complexes. The metal complexes revealed their general formula as [ML2(H2O)2] where M= Co(II),Ni(II) or Cu(II) and L=deprotonated Schiff base ligand. The in-vitro antibacterial activities of the metal complexes were tested using bacterial species Staphylococcus aureus, Bacillus cereus, Pseudomonas aeruginosa and Escherichia coli. These compounds were also tested for antifungal activities against Candida albicans and Aspergillus niger. All the Schiff bases were also screened for their anticancer activities against breast cancer MCF-7 cell line and colon cancer HT-29 cell line by sulforhodamine-B (SRB) assay. Interestingly, the Schiff base and its Co(II),Ni(II) and Cu(II) metal complexes showed superactive anticancer activity against breast cancer MCF-7 cell line while Schiff base metal complex of Co(II) showed superactive anticancer activity against colon cancer HT-29 cell line. The Schiff base ligand and its metal complexes were found to be anti-hemolytic in nature.
Authors and Affiliations
S. N. Battin, A. H Manikshete, M. R. Asabe, D. J. Sathe
Keywords
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