Synthesis, charecterization and biological evaluation of some 1, 3 and 4- Thiadiazoles schiff bases
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH - Year 2016, Vol 8, Issue 8
Abstract
Thiadiazoles and their analogues exhibit a wide variety of biological activities like antibacterial, antifungal, antitubercular, antidiabetic, anti-inflammatory, anti-convulsant, diuretic etc., In the present research work, some new series of 1,3,4- Thiadiazoles Schiffs bases were synthesized from Benzoic acid treated with thiosemicarbazide to form 2-amino-5-phenyl-1,3,4-thiadiazole derivative, the free amine group at the second position of the formed product was modified into various Schiffs bases by treating with different aromatic aldehydes to obtain the desired entity. The purity of the compounds was identified by TLC and purified by recrystallization and column chromatography. The structures were determined by IR, 1H NMR and Mass spectral data. 2-amino-5-phenyl-1, 3, 4-thiadiazole Schiff base analogues were screened for their antibacterial (Escherichia coli ATCC 25922), antifungal (Aspergillus niger ATCC 9029) by disc plate technique and antitubercular activity by use of MABA (Microplate Alamar Blue assay) analytical method on H37Rv strain of Mycobacterium tuberculosis. Based on the results shown by the synthesized compounds, all showed significant antimicrobial and antifungal activity activity. The mechanism of action of the compounds can be implicated for their cell wall disruption by inhibiting the peptidoglycon synthesis as potential antimicrobial agent or inhibiting the synthesis of mycolic acid as potential antitubercular agent.
Authors and Affiliations
Siddhanadham Arun Satyadev, Sowmya Mantha, Surendra Babu, Prashanth Varanasi
Keywords
Related Articles
- EP ID EP405204
- DOI -
- Views 112
- Downloads 0
Aware the benefits of phytoestrogens-make a safe journey to rocky road of menopause
Menopause is considered to be as an inevitable event in every woman’s life. During the menopausal transition, women may experience bothered some symptoms which may affect the quality of life. Menopause is determined by...
Comparative interventional study to assess the effectiveness of alternative hot and cold compresses vs. cold cabbage leaves on breast engorgement and pain among postnatal mothers
Comparative interventional study to assess the effectiveness of alternative hot & cold compresses vs. Cold cabbage leaves on breast engorgement and pain among postnatal mothers. This study was carried out to assess the e...
A Review Of Maternal Mortality In A Tertiary Care Center And To See The Difference Before And After Implementation of Jssy In Rajasthan
Background: MMR acts as a marker of general health of a country and is an indicator of risk of death once a woman becomes pregnant. Purpose: To review the effects of JSSY by evaluating the MMR and assessing the epidemiol...
Ultrasonographic evaluation of the circumoral musculature in skeletal class I and skeletal class ii division 1 malocclusion subjects: A comparative study
Background and Objectives: There should a balance between the forces of the tongue from within the dental arches and compensating action of the lips and cheek musculature. Alterations in function of the facial muscle can...
Knowledge and attitudes towards psychological counselling and guidance among undergraduates in sri lanka
Introduction: Students are the major recipients of psychological guidance and counselling services in a university setting where each student is enable to derive optimal educational benefits so as to actualize his/her po...