SYNTHESIS, DOCKING STUDIES AND ANTIOXIDANT ACTIVITY OF LINEAR TETRAPEPTIDE FAYV
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 7
Abstract
The linear tetrapeptide Phe-Ala-Tyr-Val (FAYV) was designed based on docking results using Schrodinger Software tool. The tetrapeptide was conveniently synthesized by solution phase peptide synthesis using Dicyclohexylcarbidomide (DCC) as coupling agent and triethyl amine as the base. Qikprop (a tool to predict drug like properties) results showed that the ligands mostly show antihypertensive and antidiabetic properties. The compounds were evaluated for antioxidant property by using 1,1-diphenyl-2-picryl-hydrazil (DPPH.) method and were found to possess significant antioxidant activity.
Authors and Affiliations
Sreekanth K. , Himaja M. , Ranjitha Anand , Asif Karigar , Mukesh Sikarwar
Keywords
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