SYNTHESIS, DOCKING STUDIES AND FREE RADICAL SCAVENGING ACTIVITY OF THE LINEAR TETRAPEPTIDE VFPF
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 6
Abstract
A rational designing of the linear tetrapeptide Val-Phe-Pro-Phe (VFPF) was done and was synthesized by solution phase peptide synthesis. The solution phase synthesis of VFPF was carried out by using ethyl-3-dimethylaminopropyl carbodiimide (EDC) as a coupling reagent and triethyl amine as a base. The molecular docking studies of the designed tetrapeptide VFPF was carried out by using Molegro Virtual Docker software for anticancer properties. VFPF was evaluated for antioxidant property by using 1,1-dipheny-2-picryl-hydrazil (DPPH) method and were found to possess moderate antioxidant activity.
Authors and Affiliations
M. Das , D. S. Agarwal , S. K. Sharma , P. Das , P. K. Rout
Keywords
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