Synthesis, Identification and Evaluation the Biological Activity for Some New Heterocyclic Compounds Derived from Schiff Bases
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 2
Abstract
This research involves synthesis some of new tetrazole, imidazolinone, thiazolidinone, and oxazepine derivatives. The first step includes formation Schiff bases (1-5) from condensation N-[(4-aminophenyl) carbamothioyl] benzamide with different aromatic aldehydein the presence of glacial acetic acid in DMF as a solvent. Four route with different reagents used for the cyclization of the prepared Schiff bases by reagent (sodium azide, 2-amino acetic acid, 2-mercapto acetic acid and phthalic anhydride) to form tetrazole (6-10), imidazolinone (11-15), Thiazolidinone (16-20), oxazepine(21-25) derivatives respectively. The structure of newly synthesized compounds were identified by spectral methods their [FTIR, and some of them by 1HNMR, 13C-NMR] and measurements some of its physical properties and some specific reactions. The chemical structures of synthesized compounds were well characterized by 1HNMR, 13CNMR, FT-IR and TLC. Also, the effects of prepared compounds in some of strains of bacteria were studied.
Authors and Affiliations
Khitam T. A. Al-Sultani
Keywords
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- EP ID EP388388
- DOI 10.9790/3008-1202013947
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