Synthesis of 3,4-Dihydro-2(1H)-Pyrimidones Via Biginelli Reaction in Organized Media Using Ionic Liquids and Solid Acid Catalysts
Journal Title: Journal of Chemistry and Applied Biochemistry - Year 2015, Vol 2, Issue 2
Abstract
5-Ethoxycarbonyl-4-aryl-6-methyl-3,4-dihydropyrimidin-2(1H)-one have been synthesized in good yield by the condensation of aromatic aldehydes, ethylacetoacetate and urea in the presence of acidic ionic liquids derived from dialkylamines as the catalyst under thermal heating in the absence of VOC. The synthesis of the target molecules revisited using acidic ion exchange resin namely Amberlite IR 120(H+) in a solid phase reaction. The two methods compared with respect to yields obtained, reaction time, ease of separation of products, cost and recyclability of the catalysts.
Authors and Affiliations
Pranab Jyoti DAS
Keywords
Related Articles
- EP ID EP354792
- DOI -
- Views 85
- Downloads 0
Multifunctional Silica Nanoparticles for Pancreatic Cancer Specific Drug Delivery and Bioimaging
Mesoporous silica nanoparticles (MSN) have attracted increasing interest as drug carriers due to their biocompatibility and robustness. In this analysis we explored the potential of MSN as nanotheranostic platform for pa...
Efficient One Pot Synthesis of 1,4-Dihydropyridines Under Solvent Free Conditions Using Carbonaceous Solid Acid Catalyst
Carbonaceous solid acid catalyst was used for convenient and efficient synthesis of 1,4-dihydropyrine (DHP) derivatives under solvent free conditions. The main advantages of these protocol includes short reaction time, h...
Synthesis of 3,4-Dihydro-2(1H)-Pyrimidones Via Biginelli Reaction in Organized Media Using Ionic Liquids and Solid Acid Catalysts
5-Ethoxycarbonyl-4-aryl-6-methyl-3,4-dihydropyrimidin-2(1H)-one have been synthesized in good yield by the condensation of aromatic aldehydes, ethylacetoacetate and urea in the presence of acidic ionic liquids derived fr...
Barium Borosilicate Glasses: Room Temperature Sorbents For Radioactive and Transition Metal Ions
The sorption behavior of borosilicate glasses with respect to radioactive metal ions like uranyl, strontium and transition metal ions like Cu2+, Ni2+ and Zn2+ have been studied in detail. Various parameters including pH,...
Transdermal Nanocarriers: New Challenges and Prospectives in the Treatment of Diabetes mellitus
In recent years nanotechnology in drug delivery systems has opened new areas for sustained release of therapeutic drugs to the site of action. The new generation of modern drug delivery systems has more advantages than t...