Synthesis of Allosteric Modulators of CB1 Cannabinoid Receptors
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 6
Abstract
Sample compounds that could act as allosteric modulators of CB1 cannabinoid receptors were synthesized. The compounds are analogues of pre-discovered bioactive molecules that bind to the CB1 allosteric site. Allosteric modulation could be a new effective approach to manipulating the endocannabinoid system by enhancing the signaling of already existing selective agonists, inverse agonists and enzyme inhibitors.Fischer indole synthesis, Vilsemeier-Haack reaction, InBr3-catalyzed sulphonation of indoles, reductive amination of indoles, bromination of indoles, were the synthesis reactions applied. Seven analogues were obtained. Percentage yield and melting point determination were performed for each compound. 1H and 13C NMR spectroscopy were also applied for characterization.
Authors and Affiliations
Ugwuonah Linda . A.
Keywords
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- EP ID EP414082
- DOI 10.9790/5736-1106016370.
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