Synthesis of Borono Fluoro Deoxy D glucose as Boron carrier for Boron neutron capture therapy (BNCT)

Journal Title: Medical Science and Discovery - Year 2017, Vol 4, Issue 7


Objective: The 18F-labeled Deoxy-D-Glucose exhibits high affinity to cancer tissue as a PET (Positron Emission Tomography) imaging agent for metastatic cancers. Complexation of 10B to 18F-DG complex may create a useful BNCT (Boron Neutron Capture Therapy) agent for cancer therapy. In previous studies, complexation and characterization of 10B with DG were evaluated and biodistribution analysis was completed successfully. Radioactive tracer labeled 10B-DG will be a useful approach to uses for BNCT applications. Methods: The 18F-DG synthesized by ion exchange and complexed with 10B(OH)3 via pH reactions. 18F-DG-10B complexation was assayed with Agilent 1260 Infinity HPLC-DAD and Agilent 6420 Triple Quad LC/MS. Complexed molecule defragmented and fragmentation products assayed with Agilent 6420 Triple Quad LC/MS for confirmation. Results: 10B-18F-DG complex was obtained with ion-exchange pH reaction successfully. Complexation of two 10B(OH)3 to 18F-DG was determined with Triple Quad LC/MS. Purification of 10B-18F-DG is currently in progress. Conclusions: Radio-labelled 10B-DG will supply new insight to research for BNCT studies. Cancer detection and therapy will be applicable in the same schedule with 10B-18F-DG complex.

Authors and Affiliations

Zafer AKAN, Taner Ozel, Gokhan Oto, Hulya Ozdemir


Related Articles

Plasma adrenomedullin levels in patients with migraine during natural attack and attack free period

Objective: The role of Calcitonin G related peptide (CGRP) in migraine has been demonsrated. The aim of this study was to examine the role of Adrenomedullin (AM) which is a member of the calcitonin/CGRP/amylin family in...

A case of zellweger syndrome accompanied by hypertrophic cardiomyopathy

Peroxisomal biogenesis disorders are a group of genetically and clinically heterogenous disorders which affect very-long chain fatty acid metabolism. Zellweger syndrome (ZS) is a rare, congenital disorder characterized b...

Comparison of the effects of two different dose algorithms in cardiac dose parameters for hodgkin lymphoma patients receiving mediastinal radiotheraphy

Objective:  This study aimed to compare pencil beam (PB) and convolution superposition (CS) dose calculation algorithms with respect to cardiac dose-volume parameters V5, V25, V30 and MHD (median heart dose) in Hodgkin l...

Prenatal diagnosis of a giant fetal cervical teratoma by magnetic resonance imaging: a case report

Fetal cervical teratomas are the rare forms of congenital teratomas with a high risk of perinatal morbidity and mortality. Imaging plays an essential role in the management of cervical teratoma and also helps in counsell...

One year experience of emergency service in patients with penetrating head trauma due to firearm

Objective: We aimed to share the features of 45 patients with firearm injuries related head traumas and our experiences in their treatments.  Methods: Our cases consisted of 36 males 45 patients in total between the ages...

Download PDF file
  • EP ID EP520739
  • DOI 10.17546/msd.331654
  • Views 14
  • Downloads 0

How To Cite

Zafer AKAN, Taner Ozel, Gokhan Oto, Hulya Ozdemir (2017). Synthesis of Borono Fluoro Deoxy D glucose as Boron carrier for Boron neutron capture therapy (BNCT). Medical Science and Discovery, 4(7), 58-64.