Synthesis of Fluorinated Pyridines as 19F NMR pH Indicators
Journal Title: JOURNAL OF ADVANCES IN CHEMISTRY - Year 2014, Vol 10, Issue 3
Abstract
This research was undertaken to synthesizes and evaluate 3,5-dihydroxymethyl-4-(2-fluorophenyl)-2,6-dimethylpyridine and 4-(fluoromethyl)-2,6-dimethylpyridine as indicators of 19F NMR pH. A comparison of 3,5-dihydroxymethyl-4-(2-fluorophenyl)-2,6-dimethylpyridine to 4-(fluoromethyl)-2,6-dimethylpyridine showed that 4-(fluoromethyl)-2,6-dimethylpyridine has a large 19F chemical shift to pH, a suitable pKa value and a good water solubility.
Authors and Affiliations
Mohammad Ali Amrollahi
Keywords
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- EP ID EP652720
- DOI 10.24297/jac.v10i3.2275
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