Synthesis of New inhibitors of the FibrillogenesisAß42: Alzheimer’s Disease
Journal Title: UNKNOWN - Year 2018, Vol 2, Issue 4
Abstract
Background: The Alzheimer’s disease (AD) is a devastating neurodegenerative disorder and the most common cause of dementia. The pathological hallmarks of AD are the presence of neurofibrillary tangles and amyloid deposits in the brain of the patient, as already defined by Alois Alzheimer in 1907. The aim of our study is to inhibit the formation the folding of amyloid protein by new synthesis of b-sheet breaker peptides. Methods: Our approach consist to develop b-sheet breaker peptides as a novel strategy to inhibit and reverse amyloidosis in AD. The synthesis was down by peptid coupling method. Results: Several b-sheet breaker peptides have been designed based on the hypothesis that amyloid deposition could be inhibited by short synthetic peptides partially homologous to the Ab region undergoing conformational changes to give rise to the amyloidogenic Ab intermediate and containing residues disrupting as aziridine and CD for the b-sheet formation university Tlemcen 2017. Conclusion:At present, there is no ideal drug for the treatment of AD, and the searches for AD drugs remain an urgent issue in the pharmaceutical community. Due to its complex pathogenesis, a single target drug cannot cure this disease fundamentally. Dual or multiple target drugs involved in two or more aspects of AD pathogenesis may generate a synergistic effect and ultimately achieve an ideal therapeutic effect.
Authors and Affiliations
Assia Keniche
Keywords
Related Articles
- EP ID EP648938
- DOI 10.26415/2572-004X-vol2iss4p315-315
- Views 47
- Downloads 0
Classification of methods for generating pseudo-CT from MRI images for MRI-alone RT
Background: Since the last decades, research have been oriented towards an MRI-alone radiation treatment planning (RTP), where MRI is used as the primary modality for imaging, delineation and dose calculation by assignin...
Brain Structures Segmentation by using Statistical Models
Background: Automatic segmentation of brain structures is a fundamental step for quantitative analysis of images in many brain’s pathologies such as Alzheimer’s, brain’s tumors or multiple sclerosis. The goal of our work...
How to Write Scientific Journals of the Highest Standards
One of the requirements of a Ph.D. or Master is to write traditional and systematic reviews, critiques, letters to editors (LTE), case reports or case studies, at least one original article, and sometimes a meta-analysis...
Medical and epidemiological impact of candidal biofilms, tridimensional architecture, and resistance
A hospital can be considered an ecosystem where the patient is found in contact with the microbial world and faces the risk of contracting an infection that is termed the nosocomial. Some opportunist pathogens yeast part...
Spontaneous Preterm Labor/ Premature Rupture Of Fetal Membranes SPL/PROM: HIGHER ASSOCIATION WITH LOW SOCIOECONOMIC STATUS
BACKGROUND:Different studies have already shown some form of correlation between low socio-economicstandards and increased rate of spontaneous preterm labor (SPL). The specific incidence ofpremature rupture of fetal memb...