SYNTHESIS OF NOVEL 2-PHENYL-1-BENZOFURAN-3(2H)-ONE DERIVATIVES AS NEW LEADS FOR ANTI-CANCER ACTIVITY
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2019, Vol 10, Issue 9
Abstract
Benzofuranone is a bicyclic ring where a benzene ring fused with a furanone. Synthetic chemistry plays a major in developing a series of potent anti-cancer agents. Bromophenyl acetonitrile was prepared from phenyl acetonitrile by bromination at an alpha position which yielded bromophenyl acetonitrile which was a lachrymator compound. Benzofuranone was synthesized by reacting benzene diols and triols with bromo phenyl acetonitrile yielded an imine derivative are converted to a ketone with treatment with hydrochloric acid then cyclized with sodium acetate. The compounds identity and purity are confirmed by spectral and analytical methods. Benzofuranone derivatives are screened anti-neoplastic activity was performed against human skin cancer cell line G361 at micro molecular concentrations. The compounds IA, IB, ID, IE, IF, IIB, IIC, IIIA, IVB, IVF, VA, VC, VD, VE was found to be with potent activity. These compounds exhibited an excellent activity while compared to reference standard doxorubicin at different micromolar concentrations as such of the synthesized compounds.
Authors and Affiliations
R. Doonaboyina et al.
Keywords
Related Articles
- EP ID EP627363
- DOI 10.13040/IJPSR.0975-8232.10(9).4223-32
- Views 78
- Downloads 0
DEMENTIA: A NEURODEGENERATIVE DISORDER
Dementia is a cognitive decline which interferes with normal psychological functioning and behavioral patterns. Dementia is as a group of neurodegenerative diseases, which affects about 1 to 4% of the world’s population...
ANTIBACTERIAL, ANTIOXIDANT, CYTOTOXICITY AND QUALITATIVE PHYTO-CHEMICAL EVALUATION OF SEED EXTRACTS OF NIGELLA SATIVA AND ITS SILVER NANOPARTICLES
Nigella sativa is considered a miracle herb plant belongs to the Ranunculaceae family, inhabitant to South Asia and South-west Asia. The most important part of the Nigella sativa plant used by human beings are seeds, mos...
CELL VIABILITY AND CYTOTOXIC EFFECT OF ACANTHOPHORA SPICIFERA (RED SEAWEED) ON HT29 COLON CANCER CELL LINE
Acanthophora Spicifera is a species of marine red seaweed and in the family Rhodomelaceae. They were freshly collected from Mandapam Coastal Area, Rameswaram Tamil Nadu, India and rinsed in seawater and packed in aseptic...
FTIR SPECTROPHOTOMETRIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF ARTEMETHER AND LUMEFANTRINE IN BULK AND FORMULATIONS
A FTIR method was developed to estimate Artemether and Lumefantrine simultaneously in bulk as well as in formulations. It is based on the measurement of absorption of radiation at the absorption band of ether at 1113.10-...
SPAN 40/TWEEN 80-BASED SOYBEAN OLEOGELS: MODELING OF GELATION KINETICS AND DRUG RELEASE
Background: Oleogel is a thermo-reversible, viscoelastic, semi-solid self-assembled preparation in which an apolar phase gets immobilized within a 3-D networked structure formed via physical or chemical interaction with...