Synthesis of Novel Pyrazole Derivatives by Vilsemeier Haack Reaction
Journal Title: International journal of Emerging Trends in Science and Technology - Year 2017, Vol 4, Issue 7
Abstract
A series of substituted carboxylic acid hydrazides on reaction with substituted acetophenone gave corresponding hydrazones which on Vilsmeier- Haack reaction resulted in corresponding formyl pyrazoles. The structures of the newly synthesized compounds were confirmed on the basis of IR and 1HNMR. And also synthesized compounds were screened for their antibacterial (Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa) and antifungal (Aspergillus niger and Candida albicans) activity. The results revealed that, compounds exhibited significant biological activity against the tested microorganisms.
Authors and Affiliations
Jyothi N. Rao
Keywords
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