Synthesis of Quinoline Derivatives by Microwave Irradiation Method and Evaluation for Their Anti-Helminthic Activity
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2019, Vol 14, Issue 1
Abstract
The search for new antihelminthic drugs is an area of active investigation with the goal of developing novel drugs in order to overcome the phenomenon of drug resistance. It is well-known that the quinoline nucleus and its derivatives play a vital role in the design of an important class of wide spectrum antihelminthic agents. The chemical entities were synthesized by Iron powder, HCl, O-Nitro Benzaldehyde, Ethanol using novel methods like conventional method and Microwave irradiation methods. The best yields, less consumption of time and purity was observed by Microwave irradiation method. From the series of compounds synthesized from 5.21a to 5.21i, 5.21c, 5.21g, and 5.21h showed significant antihelminthic activity. Compound 5.21c showed 0.69 min for paralysis of worms and the death time was recorded to be 2.19 min at a concentration of 1mg/ml.
Authors and Affiliations
K. Rama Devi, D. Ashok, K. S. K. Rao Patnaik, Raju Bathula, S. Shobha Rani, Vasudha Bhakshi
Keywords
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- EP ID EP444258
- DOI 10.9790/3008-1401021622.
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