Synthesis of Some New 3-Coumarinoyl Pyridinium and Quinolinium Bromides for their Antimicrobial Activity
Journal Title: Journal of Basic and Clinical Pharmacy - Year 2010, Vol 1, Issue 1
Abstract
3-Bromo acetyl coumarins (4a-c) on treatment with methyl and ethyl esters of nicotinic acid, isonicotinic acid (5a-d) gave 3-coumrinoyl pyridinium bromides (7a-l) and with quinoline (6) gave 3-coumarinoyl quinolinium bromides (8a-c). The structures of the final compounds were established by their spectral data. The antimicrobial activitiy of all the newly synthesized test compounds were evaluated and some of them, showed good antibacterial activity.
Authors and Affiliations
Brajesh Porwal, B. Jayashree
Keywords
Related Articles
- EP ID EP150677
- DOI -
- Views 66
- Downloads 0
Evaluation of Anthelmintic Activity of Pistia stratiotes Linn.
The ethanolic extract of the plant Pistia stratiotes (Araceae) was investigated for activity against Indian earthworms Pheretima posthuma and nematode Ascardi galli. Various concentrations (10, 20, 50 mg/ml) of ethanolic...
Rofecoxib prevents ctdsDNA against damage induced by copper sulfate and ultraviolet B radiation in vitro study
Rofecoxib is a selective cyclooxygenase COX-2 enzyme inhibitor with chemoprotective effect against cancer in experimental models. This study aimed to investigate the effect of rofecoxib against ctds DNA damage induced by...
ANTIDIABETIC EFFECT OF COMBINED AQUEOUS LEAF EXTRACT OF VERNONIA AMYGDALINA AND METFORMIN IN RATS
This study investigated the antidiabetic activity of the various combinations (ratios) of metformin (50 mg/kg) and aqueous extracts of the leaves of Vernonia amygdalina (100 mg/kg). The ratios of Extract to Metformin wer...
Synthesis of Some New 3-Coumarinoyl Pyridinium and Quinolinium Bromides for their Antimicrobial Activity
3-Bromo acetyl coumarins (4a-c) on treatment with methyl and ethyl esters of nicotinic acid, isonicotinic acid (5a-d) gave 3-coumrinoyl pyridinium bromides (7a-l) and with quinoline (6) gave 3-coumarinoyl quinolinium bro...
CONTROLLED RELEASE MATRIX UNCOATED TABLETS OF ENALAPRIL MALEATE USING HPMC ALONE
Hydroxy propyl methyl cellulose (HPMC) is generally combined with hydrophobic polymers in fabricating oral controlled solid dosage forms. This study evaluated the utility of diverse grades of HPMC in developing a control...