Synthesis of The Copolymer P(VAc-Co-4VP) For Developing A New SPECT Radioactive Tracer
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 2
Abstract
SPECT is an imaging technique used for diagnostic purposes in Nuclear Medicine. SPECT provides images of superior quality to X-Rays imaging techniques that are normally used during vascular embolization procedures. Vascular embolization is a minimally invasive technique used to reduce the size of a tumor by applying polymeric microspheres. Therefore, radioiodinated polymeric microspheres can be used for SPECT imaging during vascular embolization to make this procedure more efficient and safer. As phenolic compounds allow radioiodination in high yields, these substances can be selected for both copolymerization and radioiodination. In this work, we evaluate the copolymerization between vinyl acetate and 4-vinyl phenol for further radioiodination. Respectively, bulk polymerization tests and conversion study showed that the 4-vinyl phenol must be used at 0.5 % w/w content and the copolymer maximum conversion is reached after 120 min. In addition, this phenolic comonomer affects the polymer mass distribution. Finally, FTIR, RMN, TGA and DSC results showed that the 4-vinyl phenol is present in the polymer backbone. Therefore, these results indicate that the designed copolymer poly (vinyl acetate-co-4-vinyl phenol) (PVAc-co-4VP) was successfully obtained.
Authors and Affiliations
Luciana Carvalheira, Marcel G. Martins, José C. Pinto, Marcio Nele
Keywords
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- EP ID EP413996
- DOI 10.9790/5736-1102034551.
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