SYNTHESIS OF ZNO NANOGEL FOR THE TREATMENT OF SUPERFICIAL SKIN MICROBIAL INFECTIONS
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 2
Abstract
Zinc oxide (ZnO) nanogel is an antimicrobial gel comprising of ZnO nanoparticles. Since, in nanoparticles, the surface to volume ratio is very large, therefore, ZnO nanogel is more effective for the treatment of superficial skin microbial infections as compared to other gels comprising ZnO and that has processed through traditional methods. Generally, infected skins are affected by bacterial strains which are attached to the surface of the skin by forming biofilms. The cause of attachment of these biofilms with the skin may be due to the electrostatic, van der walls, dipole-dipole and H-bonding hydrophobic types of interactions. ZnO nanogel when applied to the microbial infected skin reduces the microbial adhesion and biofilm formation. This screening characteristic of gel is due to the presence of ZnO nanoparticles of pore diameter 12.4 nm in the gel. The nanoparticles of ZnO is synthesized using sol-gel method and characterized by X - ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy dispersive spectroscopy (EDS) and high resolution transmission scanning electron microscopy (HRTEM). The minimum inhibitory concentration (MIC) data tells that ZnO nanoparticles of such a small pore diameter inhibit the growth of microbes present on the skin surface.
Authors and Affiliations
Mohammad Mujahid
Keywords
Related Articles
- EP ID EP294669
- DOI 10.22270/jddt.v7i2.1391
- Views 124
- Downloads 0
Mini Review: Role of Inhibitors in Cancer Therapy
The report presented details on different types of inhibitors and their localized actions on cells. The review presented details from specific studies conducted in cancer clinical care. The work also presented reviews on...
INCREDIBLE TASTE MASKING OF CLARITHROMYCIN
Clarithromycin has poor acceptance by pediatric and geriatric patients due to bitter taste. Usually, in dry syrup formulations, high concentration of sugar is used for taste masking. But high consumption of sugar is rela...
FORMULATION, DEVELOPMENT AND CHARACTERIZATION OF SOLID LIPID NANOPARTICLES OF GEMCITABINE HYDROCHLORIDE
Gemcitabine Hydrochloride is a BCS class III drug of choice in the treatment of cancer, as a single or in combination chemotherapy. However, its bioavailability is a major concern due to its short half-life. Solid lipid...
INDIGENOUS USES AND PHYTOCHEMICAL CONTENTS OF PLANTS USED IN THE TREATMENT OF MENSTRUAL DISORDERS AND AFTER- CHILD BIRTH PROBLEMS IN ABEOKUTA SOUTH LOCAL GOVERNMENT AREA OF OGUN STATE, NIGERIA
A survey of plants used for the treatment of menstrual disorders and after-child birth problems was conducted in Abeokuta South Local Government. Hundred (100) questionnaires were administered using multi stage sampling...
ELUCIDATING THE STRUCTURAL REQUIREMENTS OF NOVEL PAZOPANIB DERIVATIVES TOWARDS TYROSINE KINASE INHIBITORY ACTIVITY THROUGH CLASSICAL HANSCH AND DE-NOVO APPROACH
Quantitative structure–activity relationship (QSAR) and Molecular modeling study have been performed on a series of novel Pazopanib derivatives by using the Mixed Hansch Fujita-Ban approach and employing AM1 calculations...