Synthesis, physical and chemical properties of 5-(phenoxymethylene)-4-R-1,2,4-triazol-3-thiones derivatives, which contain alkyl- and arylnitrile fragments
Journal Title: Фармацевтичний журнал - Year 2015, Vol 4, Issue 4
Abstract
Ukraine takes the second place in Europe for the dissemination of cancer. Ukrainian pharmaceutical market practically doesn’t have domestic anti-tumor drugs. That’s why, many scientists of pharmaceutical industry work in this direction. The searching of biologically active substances among derivatives of 1,2,4-triazole is actually for today. Anastrozole and Letrozole are enough known like anti-tumor drugs which contain in their structures the core of 1,2,4-triazole and nitrile groups. The aim of our work is purposeful synthesis a number of new highly effective compounds 2-((5-(phenoxymethylene)-4-R-4H-1,2,4-triazole-3-yl)thio)acetonitriles and 2-, 3-, 4-(((5-(phenoxymethylene)-4-R-4H-1,2,4-triazole-3-yl)thio)methyl)benzo-nitriles, research of its physical and chemical properties. The 5-(phenoxymethylene)-4-R-1,2,4-triazole-3-thiones, which contain alkyl- and arylnitrile groups has been synthesized and its effective methods obtaining have been set. The structure of synthesized compounds has been confirmed by modern complex of physical and chemical methods of analysis. The synthesized compounds with alkyl- and arylnitrile functional groups will become the basis for further modification of the structure to increase results or expand the range of the biological activity.
Authors and Affiliations
Yu. M. Kucheryavyi, A. G. Kaplaushenko
Keywords
Related Articles
- EP ID EP586485
- DOI -
- Views 61
- Downloads 0
Clinical and economic analysis of pharmacotherapy for patients with ulcer in the terms of prepaid funds
Digestive diseases are the third leading cause of appeals in all age groups for medical help after the pathologies of the circulatory and respiratory system. In Ukraine, the number of patients needing specialized gastroe...
Use of modeling in the study of economic burden of influenza in the elderly population in Central and Eastern European countries
The economic burden of the incidence of influenza and ARI requires careful study, since annually about 15% of the world's population suffers from these diseases. In addition, the flu can cause complications that are dang...
Identification and quantitative determination of the flavonoids of the complex dense extract of st. john's wort herb and pot marigold flowers
Common Saint-John's wort (Hypericum perforatum) and pot marigold (Calendula officinalis) are rich in such biologically active substances (BAS) as carotene, ascorbic acid, essential oils, vitamins, tannin and resinous sub...
Testing of the mutagenic potential of N-(γ-aminobuturyl)-1-aza-15-crown-5 hydrochloride in Ames test microplate modification
In recent years, studies in the field of chemical mutagenesis have undergone significant development, due to the introduction of a large number of different chemicals and scientific advances in the creation and use of ne...
Development and validation of the method for determination of encapsulation efficiency of cytochrome c in liposomes
A strategic pathway in creating high-potent medical products is with targeted therapeutic systems that are based on nanoparticles of various structure. Such particles are capable of providing a targeted effect and an inc...