SYNTHESIS, REACTIVITY, ANTI-OXIDANT AND CYTOTOXICITY EVALUATION OF SOME COUMARIN DERIVATIVES
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2018, Vol 5, Issue 8
Abstract
In the present work 3-amino-8-methoxy coumarin was prepared either by microwave irradiation or by convential method. It was used as a key starting material for the synthesis of triazole thione (8), Schiffs’ bases (10), thiazolone (11a-d), pyrimidinethione (13), aminothiazole (15) and isoxazole (18) derivatives through its reaction with different reagents. The structures of the newly synthesized compounds were elucidated on the basis of their elemental analysis and by using different spectroscopic methods. The free radical scavenging activity of some newly synthesized derivatives was determined by measuring their interaction with the stable free radical DPPH and some compounds have shown encouraging antioxidant activity. Also, they were screened for their in-vitro cytotoxicity against two human cancer cell lines namely HEIA cells (human cervical carcinoma) and A-549 cells (human lung cancer cell line). The IC50 values (the sample concentration that produces 50% reduction in cell growth) in μg/mL showed that some of the tested compounds exhibited significant cytotoxic effect.
Authors and Affiliations
Shaimaa H. Abd El Monem
THERAPEUTIC EFFECT OF GARCINIA KOLA AGAINST CCL4 INDUCED HEPATOXICITY IN MALE ALBINO RATS
Garcinia kola seed (bitter kola) is used in traditional medicine for the treatment of various disorders, including hepatic disorders. The present study was aimed at evaluating efficacy of Garcinia kola seed in protecting...
SERUM CALCIUM IN PRIMARY POSTPARTUM HAEMORRHAGE
Background: Postpartum haemorrhage may cause maternal mortality. Uterine atony is a major cause of primary post-partum haemorrhage (PPH). Calcium plays a role in uterine contraction and may contribute to the causation of...
ANAESTHETIC CHALLENGES IN ADULT LAPAROSCOPIC BARIATRIC SURGERY
Obesity represents a significant and growing problem around the globe. Aside from the impairment of an individual patient, the negative consequences impose a significant economic burden for many health care systems.[1] F...
PITUITARY STALK INTERRUPTION SYNDROME: CASE REPORT WITH ISOLATED GROWTH HORMONE DEFICIENCY
Pituitary stalk interruption syndrome is characterized by a triad of thin or interrupted pituitary stalk, aplasia or hypoplasia of the anterior pituitary and absent or ectopic posterior pituitary seen on magnetic resonan...
ANTIMICROBIAL SENSITIVITY PATTERN IN SURGICAL PATIENT ADMITTED TO INTENSIVE CARE UNIT, NORTHWEST REGION, KINGDOM OF SAUDI ARABIA
Antimicrobial resistance is challenging for the health care professionals especially in intensive care unit. Most of the hospitals in developing countries yet to understand this phenomenon in order to succeed in antimicr...