Synthesis,Characterization, Biological Evaluation and anti corrosion activity of some new bis-piperidone Derivatives
Journal Title: International journal of Advanced Biological and Biomedical Research - Year 2013, Vol 1, Issue 2
Abstract
Aseries of piperidine derivatives was synthesis by the reaction between substituted benzaldhyde ,pentanone-3,and ammonium acetate by refluxining for 1-2 hr in ethanol and the derivatives refluxed with (4,4'-Diaminodiphenyl sulphone) yielded bispiperidine ,the structures of the synthesized compounds were confirmed by spectroscopy analysis , The reported compounds were screened for their antibacterial activities against : Staphylococcus aureus, Klebsiella,Escherichia coli,pseudomonas aeruginosa,Salmonilla typhi, Enterobacter. The synthesized piperidone-4 were tested to determine their ability to inhibit corrosion of mild steel in 1mol.L-1 H2SO4 and measured by polarization measurements . Which showed that these compounds act as mixed-type inhibitors. The studies revealed that the nitrogen of Schiff base and sulfur atome ,piperidine moiety ,and the phenyl ring assist largely in corrosion control.
Authors and Affiliations
Kholoud Fahed Hamak| Department of chemistry, Collegeof Science, Damascus University
Keywords
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