Systemic Absorption of Gentamicin Irrigation in Joint Replacement Surgery: A cause of concern
Journal Title: Malaysian Orthopaedic Journal - Year 2008, Vol 2, Issue 2
Abstract
Gentamicin, whether administered either intravenously, incorporated into bone cement or for local intra-operative irrigation, is a commonly used antibiotic in orthopaedic practice. The former two have been well studied, however the literature on the therapeutic efficacy and safety of gentamicin irrigation is sparse. The objective of this study was to assess systemic absorption of gentamicin irrigation in joint replacement surgery. This was a non-randomised, prospective study. Ninety-eight patients (group A) who underwent total joint replacement and 40 patients (group B) who underwent hemi-arthroplasty were treated intraoperatively with gentamicin irrigation. Serum gentamicin levels were assayed at 4 hours and 24 hours post-surgery. Sixteen of 98 patients in group A (16%) and 12 out of 40 patients in group B (30%) were found to have serum gentamicin level above 2mcg/ml at 4 hours post-surgery. We conclude that intra-articular gentamicin irrigation is systemically absorbed at substantial levels.
Authors and Affiliations
KH Lee, ABY Ng, TB Tan, K Mossinac, BC Se To
Keywords
Related Articles
- EP ID EP298122
- DOI -
- Views 119
- Downloads 0
Modified One-third Tubular Plate with Hook for Distal Lateral Malleolus Fracture Fixation
Fracture of the lateral malleolus is a commonly encountered problem in the orthopaedic fraternity. Among the lateral malleolus fractures, Weber type B is the most common injury, accounting for 60% of all ankle fractures....
Toe-tourniquet syndrome: A rare potentially devastating entity
Toe-tourniquet syndrome is a rare and commonly misdiagnosed condition caused by a hair or a fiber wrapped around digits (fingers and toes). A four months baby girl who was crying and presented with redness and swelling a...
Langerhans Cell Histiocytosis with Extensive Spinal and Thyroid Gland Involvement Presenting with Quadriparesis: An Unusual Case in an Adult Patient
Langerhans cell histiocytosis of the spine frequently presents as a solitary lesion and rarely results in neurological deficit. Involvement of thyroid tissue is also rare, even in multifocal disease presentations. We pre...
Is A New Combination of Tendon Transfers For Radial Nerve Palsy (RNP) Needed?
Radial nerve palsy following traumatic humeral diaphyseal fractures occurs uncommonly. Most recover with good outcome. However the cases with poor outcome or recovery will have tendon transfers to regain the lost functio...
Periprosthetic Fractures after Total Knee Arthroplasty: the Influence of Pre-Operative Mechanical Factors versus Intraoperative Factors
INTRODUCTION: Periprosthetic fractures are a devastating complication following total knee arthroplasty. Little is known about the effect of mechanical factors on the incidence of periprosthetic fractures. The aim of thi...