Systemic Review: Role of Tissue Plasminogen Activator for Acute Ischemic Stroke
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 70, Issue 7
Abstract
<strong>Background: </strong>Using recombinant tissue plasminogen activator (rt-PA) during the first 3 h up to 6 h of stroke was allowed to reduce the poor functional consequences of stroke.<br /> <strong>Objectives: </strong>assess the effects of intravenous dosage of rt-PA during the first 6 h after on early and late outcomes of acute ischemic stroke (AIS).<br /> <strong>Methods: </strong>all studies regarding the intravenous rt-PA given within 6 h of onset of acute ischemic stroke up to 2016 were searched the outcomes, and the mortality rates were evaluated at the final follow up.<br /> <strong>Results: </strong>There was a significant increase in functional outcome by using IV-tPA significantly (p <0.01).<br /> A significant decrease was found in intracranial hemorrhage in the patients treated with IV-tPA. The mortality rates were significantly decreased at the end of the follow up period in patients treated with IV-tPA.<br /> <strong>Conclusion: </strong>The study indicated that using intravenous rt-PA could increase the number of living patients favorable outcome, less disabilities and intracranial hemorrhage among acute ischemic stroke patients during the first 6 hours.<br /> <strong> </strong>
Authors and Affiliations
Eman Helal
Keywords
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- EP ID EP583623
- DOI 10.12816/0044536
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