Systemic therapy for advanced hepatocellular carcinoma
Journal Title: Journal of Clinical Hepatology - Year 2024, Vol 40, Issue 11
Abstract
Hepatocellular carcinoma （HCC） is one of the most common malignancies with high morbidity and mortality rates worldwide. With the advances in molecular biology and tumor immunology， molecular-targeted agents represented by tyrosine kinase inhibitors （such as sorafenib and lenvatinib） and immunotherapy represented by PD-1/PD-L1 monoclonal antibodies have brought hope for patients with advanced HCC. The combination of immunotherapy and anti-angiogenic therapy can further improve the treatment outcome of patients. In addition， the optimization and integration of stereotactic body radiotherapy， local treatment， and systemic treatment may maximize the benefits of patients. In the future， through a deep understanding of the heterogeneity of HCC， the development of precision molecular subtyping and individualized treatment， and the establishment of a multidisciplinary collaborative diagnosis and treatment system， systemic therapy is expected to achieve long-term management of advanced HCC. This article reviews the current status and advances in systemic therapy for advanced HCC.
Authors and Affiliations
Jiahao XU, Dongxu YIN, Yuchen LI, Fujie CHEN, Mingda WANG, Tian YANG
Keywords
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- EP ID EP753504
- DOI 10.12449/JCH241127
- Views 7
- Downloads 1
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