Tadalafil versus Papaverine in Pharmaco Penile Duplex Ultrasonography-A Comparative Study
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 3
Abstract
ABSTRACT Introduction: ‘Erectile Dysfunction’ (ED) traditionally defined as inability to achieve and/or maintain an erection for satisfactory sexual intercourse. It can affect men of all age groups, but prevalence increases with age. Aim: The aim of the present study was to assess whether oral Tadalafil is as useful as injectable Papaverine in the evaluation of men with ED. Materials and Methods: Pharmaco penile duplex ultrasonography was done using a linear broadband phased array transducer (7–12 MHz) on an E-Saote MyLab 60 ultrasound-colour Doppler system on 36 patients over a period of two years. Visual grading score for erection, cavernosal artery diameter, Peak Systolic Velocity (PSV), End Diastolic Velocity (EDV), Resistive Index (RI) and Acceleration Time (AT) were obtained in all patients following administration of oral Tadalafil and intracavernosal injection of Papaverine in one week gap. All the data was analysed using SPSS software version 22.0 (SPSS Inc., Armonk, NY, USA). Results: In Tadalafil mode, visual grading for erectile response was E1 in four patients, E2 in eight patients, E3 in seven patients, E4 in two patients and E5 in 15 patients. In Papaverine mode, visual grading for erectile response was E1 in three patients, E2 in seven patients, E3 in five patients, E4 in two patients and E5 in 19 patients. In Tadalafil mode, a total of 17 patients showed evidence of arterial insufficiency and two patients showed evidence of venous insufficiency. In Papaverine mode, a total of 12 patients showed evidence of arterial insufficiency, two patients showed evidence of venous insufficiency and one patient showed indeterminate results. Conclusion: In the present study, oral Tadalafil contributed significantly in the evaluation of ED and showed statistically significant results similar to intracavernosal injection of Papaverine.
Authors and Affiliations
Phani Chakravarty Mutnuru, Rahul Devraj, Harshavardhana Kuruba Ramanjaneyulu, Ramakrishna Narayanan, Rammurti Susarla, Jyotsna Yarlagadda
Keywords
Related Articles
- EP ID EP514602
- DOI 10.7860/JCDR/2018/33883.11299
- Views 43
- Downloads 0
Granular Cell Tumour of the Chest Wall: FNA Diagnosis with a Review of Literature and Elaboration of Cytological Mimickers
Granular Cell Tumours (GCTs) are uncommon tumours which can be confused with other benign soft tissue tumours on clinical examination. Fine Needle Aspiration Cytology (FNAC) plays a significant role in their diagnosis. T...
The Leverage Method: A Novel Technique for Difficult Temporomandibular Joint Reduction
Letter to Editor
Degenerated Cystic Uterine Myoma Mimicking Postpartum Haemoperitonium
Haemoperitoneum due to spontaneous haemorrhage of intraleiomyoma is a very rare complication of uterine myoma. Acute complications of uterine myoma are seldom seen, but it may be fatal. We hereby report case of a female,...
Efficacy of Green Tea Extract for Treatment of Dry Eye and Meibomian Gland Dysfunction; A Double-blind Randomized Controlled Clinical Trial Study
Introduction: With an incidence rate of 9%, dry eye is a common problem of the ocular surface, especially in patients more than 40-year-old. Green tea extract has anti-oxidative, anti-bacterial, anti-androgen, and immuno...
LMP1-Positive Composite Tumour of Larynx: A Diagnostic Quandary
ABSTRACT Malignant spindle cell tumours of the larynx are rare, of which the most common are Spindle Cell Squamous Carcinomas (SCSCs). Sarcomas are extremely infrequent in the larynx. Composite tumours, further, are quit...