Tamoxifen: Pharmacokinetics and Pharmacodynamics
Journal Title: Open Access Journal of Pharmaceutical Research - Year 2017, Vol 1, Issue 8
Abstract
Tamoxifen is the hormone therapy of choice in pre-menopausal estrogen receptor positive breast cancer in women and sometimes in post-menopausal women. The environmental and genetic factors widely affect the pharmacokinetic parameters of a drug and this effect is known as pharmgeonetics. The pharmacokinetic parameters that are what a body does with the drug, such as bioavailability, half-life, distribution and excretion, has primary importance in the treatment of a disease. The pharmacodynamic parameters which elaborate what a drug does with the body like side effects and positive symptoms are the pillars of therapeutic outcome. In depth knowledge of both parameters is essential to get maximum benefits from a treatment plan in a disease for example breast cancer. This review enlightens the pharmacological aspects of tamoxifen in detail.
Authors and Affiliations
Shahbaz K*
Keywords
Related Articles
- EP ID EP745890
- DOI 10.23880/oajpr-16000143
- Views 43
- Downloads 0
Determination of Hydrochlorothiazide in Plasma by High Performance Liquid Chromatography (HPLC)
Retention times for hydrochlorothiazide (HCTZ) and chlorothiazide (CTZ, internal standard) are highly temperature- (20°-26°) as well as pH-dependent (3.5-6.3). Separation of both drugs is maximized in the pH range 6.3 to...
Fungal Protein (Mycoprotein) What to Know About
Microbes in general and fungi especially are promising biotechnological tools that are used for green synthesis of numerous products. Fungi in particular are potent producers of many important compounds used in differen...
A Comparative Study of Soap and Syndet Bars: Formulation, Benefits and Efficacy in Skin Care
This review presents a comprehensive comparative analysis of soap and syndet bars in the context of their formulation, benefits, and efficacy in skin care. The study examines the underlying compositions, manufacturing p...
Novel Vesicular Drug Delivery Systems Proniosomes
These proniosomes, which are dry surfactant-coated particles that form niosomal dispersion in hot aqueous fluids immediately on stirring, are the subject of this review paper. It is easier to transport, distribute, stor...
Antidiabetic Activity of Pereskia Bleo Aqueous Extracts in Alloxan Induced Diabetic Rats
Pereskia bleo Kunth (Cactaceae) is locally known as ‘Jarum tujuh bilah’. It has been used traditionally by local Malays for the treatment of diabetes. This study investigates the antidiabetic activity of aqueous extract...