Taraxacum officinale extract induces antitumorigenic effects in ovarian carcinoma cell lines
Journal Title: European Journal of Gynaecological Oncology - Year 2019, Vol 40, Issue 1
Abstract
Purpose of Investigation: Patients suffering from ovarian cancer often use mistletoe preparations in combination with Taraxacum officinale (dandelion) extracts as supplementary therapy to conventional medicine. However, scientific data concerning antitumorigenic effects of Taraxacum extracts and co-treatment with mistletoe extracts are insufficient. Materials and Methods: Sensitivity of cancer cell lines towards a Taraxacum extract was determined by cell viability assays. Effects of Taraxacum on cell proliferation, cell cycle distribution, mitochondrial integrity, as well as migration and invasion were investigated in ovarian carcinoma cells (NIH:OVCAR-3 and SKOV-3). Results: Taraxacum extract caused a reduction of cell viability in a panel of adult cancer cell lines (cervical-, colon-, endometrial-, hepatocellular-, lung-, mamma-, ovarian-, pancreatic-, and urinary bladder carcinoma), whereby gynecological tumors were particularly susceptible. Inhibitory effects on cell viability, migration, mitochondrial integrity, and induction of apoptosis were observed in ovarian cancer cells. Combined therapy with mistletoe extracts revealed synergistic effects. Conclusion: This study provides first preclinical data on the antitumorigenic effects of Taraxacum and demonstrates the effectiveness of a combination treatment with mistletoe extracts in ovarian cancer cells.
Authors and Affiliations
K. Menke, M. Schwermer, J. Felenda, C. Beckmann, F. Stintzing, A. Voigt, T. J. Zuzak
Keywords
Related Articles
- EP ID EP663046
- DOI 10.12892/ejgo4460.2019
- Views 66
- Downloads 0
Expression of FOXA1 in breast cancer and the significance
Objective: The aim of this study to examine the expression of FOXA1, ER, and PR in breast cancer and investigate the association between FOXA1 expression and clinical parameters. Materials and Methods: One hundred one ca...
Clinical features and prognostic factors associated with malignant transformation of ovarian mature cystic teratoma
Purpose: To explore the clinical characteristics and identify potential prognostic factors associated with malignant transformation (MT) of ovarian mature cystic teratoma (MCT). Materials and Methods: This study analyzed...
Concurrent chemoradiotherapy combined with immunotherapy is superior to traditional concurrent chemoradiotherapy in the treatment of advanced cervical cancer
Purpose of investigation: In advanced cervical cancer, traditional therapy included concurrent chemoradiotherapy (CCRT), pelvic radiotherapy, and brachytherapy. In the last few years, the development of using of immunoth...
The association of microcystic, elongated, and fragmented (MELF) invasion pattern in endometrial carcinomas with prognostic factors
Purpose: One of the most important prognostic factors for endometrial carcinoma (EC) is myometrial invasion. Microcystic, elongated, and fragmented (MELF) myometrial invasion (MI) pattern is also important in terms of di...
The pleiotropic factor Y-box binding protein-1 enhances the anti-proliferative efficacy of 4-hydroxytamoxifen and fulvestrant on breast cancer cells in vitro
Purpose of investigation: The pleiotropic factor Y-box binding protein-1 (YB-1) is clinically correlated with breast cancer patients’ poor outcome. Due to the intereference of YB-1 with the estrogen receptor, the authors...