Taraxacum officinale extract induces antitumorigenic effects in ovarian carcinoma cell lines
Journal Title: European Journal of Gynaecological Oncology - Year 2019, Vol 40, Issue 1
Abstract
Purpose of Investigation: Patients suffering from ovarian cancer often use mistletoe preparations in combination with Taraxacum officinale (dandelion) extracts as supplementary therapy to conventional medicine. However, scientific data concerning antitumorigenic effects of Taraxacum extracts and co-treatment with mistletoe extracts are insufficient. Materials and Methods: Sensitivity of cancer cell lines towards a Taraxacum extract was determined by cell viability assays. Effects of Taraxacum on cell proliferation, cell cycle distribution, mitochondrial integrity, as well as migration and invasion were investigated in ovarian carcinoma cells (NIH:OVCAR-3 and SKOV-3). Results: Taraxacum extract caused a reduction of cell viability in a panel of adult cancer cell lines (cervical-, colon-, endometrial-, hepatocellular-, lung-, mamma-, ovarian-, pancreatic-, and urinary bladder carcinoma), whereby gynecological tumors were particularly susceptible. Inhibitory effects on cell viability, migration, mitochondrial integrity, and induction of apoptosis were observed in ovarian cancer cells. Combined therapy with mistletoe extracts revealed synergistic effects. Conclusion: This study provides first preclinical data on the antitumorigenic effects of Taraxacum and demonstrates the effectiveness of a combination treatment with mistletoe extracts in ovarian cancer cells.
Authors and Affiliations
K. Menke, M. Schwermer, J. Felenda, C. Beckmann, F. Stintzing, A. Voigt, T. J. Zuzak
Keywords
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- EP ID EP663046
- DOI 10.12892/ejgo4460.2019
- Views 48
- Downloads 0
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