Targeted Agents and Resistance Mechanism in Renal Cell Cancer
Journal Title: Üroonkoloji Bülteni - Year 2019, Vol 18, Issue 2
Abstract
Renal cell carcinoma (RCC) exhibits multidrug resistance protein P-glycoprotein expression due to the proximal tubular origin and in this regard, it is resistant to a large number of cytotoxic chemotherapy. The identification of the molecular pathogenesis, genetics, and epigenetics of RCC has led to new target points such as vascular endothelial growth factor. Tyrosine kinase inhibitors have been used mainly for treatment, but recently, immune checkpoint inhibitors have also been used in the treatment of RCC. Despite these treatments, response rates are not sufficient in the majority of patients. Primary resistance or acquired resistance to the treatment might be seen. Defining these resistance mechanisms will contribute to the management of the treatment and will help in to identify new treatment targets. In this review, we focus on the molecular mechanisms and resistance mechanisms of targeted-therapy.
Authors and Affiliations
Shaghayegh Rezapourbehnagh, Hatime Arzu Yaşar, Çağatay Arslan, Yüksel Ürün
Keywords
Related Articles
- EP ID EP588923
- DOI 10.4274/uob.galenos.2018.1090
- Views 113
- Downloads 0
Partial Urethrectomy for Female Urethral Transitional Epithelial Cell Carcinoma
To present a female case of partial urethrectomy and the following adjuvant chemo-radio-therapy for urethral transitional epithelial cell carcinoma originating from distal urethra in the light of literature. The patient...
Sentinel Lymph Node Biopsy in Lymphadenectomy for Prostate Cancer
Performing the sentinel lymph node (SLN) biopsy during prostate cancer staging aims to provide more accurate nodal staging with low complications than pelvic lymph node dissection. SLN might be found outside the extended...
Neutropenic Fever, Skin and Eye Toxicities Develops During Docetaxel Treatment in Metastatic Prostate Cancer: A Case Report
Prostate cancer is one of the most common tumors in men. Docetaxel and prednisone treatment are accepted as standard therapy in castration-resistant prostate cancer patients. Docetaxel is a chemotherapeutic drug of the t...
A Rare Presentation of Germ Cell Neoplasia: Persistant Müllerian Duct Syndrome
Persistent Müllerian duct syndrome is a rare form of pseudohermaphroditism. This article is made of two case reports showing malignant transformation. The first case was a 36-year-old male who presented with infertility....
The Clinical, Oncological, Functional and Surgical Outcomes of Patients Who Underwent Adrenalectomy
Objective: Adrenal masses are often benign and rarely malignant. They may be also hormonally functional or non-functional. It is possible to treat these masses curatively with open and laparoscopic adrenalectomy. The aim...