TARGETED DRUG DELIVERY SYSTEM: AN OVERVIEW
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 10
Abstract
Targeted drug delivery is an advanced method of delivering drugs to the patients in such targeted sequences that increases the concentration of the delivered drug to the targeted body part of interest only which in turn improves efficacy of treatment by reducing side effects of drugs administration. The brain is a delicate organ, and nature has very efficiently protected it. The drug accessibility to the central nervous system is limited by the blood brain barrier(BBB).Various brain disorder are Parkinson, Alzheimer, Meningitis, Brain abscess, Epilepsy, Multiple sclerosis etc. The management of brain related diseases with the present available therapeutic system is very difficult, as insuffient amount of drug reaches to the brain, due to the highly lipophilic nature of blood-brain barrier (BBB). Drug delivery to the brain requires advances in drug delivery technologies. Due to the presence of blood brain barrier only small lipid soluble drug in the circulation are delivered to the brain cells. The most distressing fact about delivery of drug to the CNS is the presence of BBB that have a tendency to impair the drug distribution. The net amount of delivered drug (medicinal agent) and its capability to gain access to the pertinent target sites are the main considering points for CNS drug development. Therefore, practical strategies are required for mediating the drug transport across blood brain barrier. The goal of a targeted drug delivery system is to prolong, localize, target and have a protected drug interaction with diseased tissue.
Authors and Affiliations
John Wesley I.
Keywords
Related Articles
- EP ID EP628082
- DOI -
- Views 128
- Downloads 0
SMOKING IS STILL SUSPECTED TO AFFECTS THE SEMEN PARAMETER OR NOT META-ANALYSIS REVIEW
numerous studies have identified specific body systems affected by the hazardous effects of the cigarette smoking particularly the respiratory and cardiovascular systems. the effect of smoking on male reproduction has al...
DESIGN, DEVELOPMENT AND EVALUATION OF LOMEFLOXACIN HYDROCHLORIDE NIOSOMAL GUM BASED IN SITU GELS FOR OTIC DRUG DELIVERY
The aim of the present study was to design, formulate and evaluate lomefloxacin Hcl niosomal in situ gels to provide broad spectrum antibacterial activity for the treatment of ear infections aiming to increase drug conce...
EFFECTS OF FLAVONOIDS EXTRACTED FROM ARTEMISIA VULGARIS ON INDUCED HYPERURICEMIA IN MICE
Objective: The aim of the study was to investigate the hypouricemic effect of flavonoids extracted from aerial parts of Artemisia vulgaris on hyperuricemic mice. Methods: Forty albino mice were divided into four groups....
CARDIAC RISK FACTOR IN RELATION TO LEAD LEVEL AMONG SUDANESE WORKERS IN GASOLINE STATIONS
Background: Occupational lead exposure is one of the major public health problems, no previous publishd research was conducted on lead exposure gasoline station workers in khratoum state. Objectives: The present study ai...
STUDY OF ANTIOXIDENT AND ANTIMICROBIAL ACTIVITY OF PHALARIS CANARIENSIS SEED IN DIFFERENT EXTRACTS
Phalaris canariensis seed extracts are used to assess their antimicrobial and antioxidant activity. Extracts are made through polarity decreasing order od solvents where aqueous, ethanol, ethyl acetate, chloroform, cyclo...