Targeted gene therapy in the management of osteoarthritis: back to the future with great expectations
Journal Title: International Journal of Clinical Rheumatology - Year 2017, Vol 12, Issue 4
Abstract
Osteoarthritis (OA) is a degenerative joint disease of the articular cartilage with subchondral bone remodeling and secondary inflammation [1]. OA is the most common joint disease worldwide, a chief cause of chronic disability especially in the elderly. Chitosan-graft-polyethylenimine/DNA nanoparticles as novel non-viral gene vectors for gene therapy of OA have been developed. These nanoparticles with improved transfection efficiency and low cytotoxicity may be safe and efficient for gene delivery to both chondrocytes and synoviocytes
Authors and Affiliations
Tamer A Gheita
Keywords
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