Abstract

Myostatin is a protein well described for its role in decelerating muscle anabolism. Most studies targeting the Myostatin pathway were performed in muscle wasting diseases. Recent studies unveil a potential approach to interfere with the Myostatin pathway to facilitate wound healing. We therefore reviewed the present literature for aiming the Myostatin pathway as a potential treatment option in impaired skin healing. The inhibition of Myostatin may facilitate wound healing through different ways including reduced scarring, decreased inflammatory response and altered distribution of fat. Drugs targeting the Myostatin pathway are available for muscle wasting diseases but preclinical and clinical studies with those inhibitors are required to evaluate their potential in skin healing.

Authors and Affiliations