Targeting the Ether-à-go-go ion channels in cancer therapy: current knowledge and future perspectives
Journal Title: Journal of Experimental and Molecular Biology - Year 2018, Vol 19, Issue 1
Abstract
Members of the Ether-à-go-go (Eag) group of potassium channels, including the human Ether-à-go-go (hEag) and the human Ether-à-go-go-related gene (hERG) ion channels, have been shown to play important roles in cancer pathogenesis and to regulate many aspects of tumour development. It was shown that they are frequently overexpressed or ectopically expressed in different human cancers, which, combined with their cell surface expression, led to different attempts at finding their therapeutic potential as promising cancer therapy targets. This review summarizes the current knowledge drawn from the results of independent studies performed to identify sought-after alternatives of targeting these ion channels in cancer therapy.
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Targeting the Ether-à-go-go ion channels in cancer therapy: current knowledge and future perspectives
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