Taste Masked Suspension
Journal Title: The Pharma Innovation - Year 2012, Vol 1, Issue 2
Abstract
Children are frequently failed to take medications properly because of unpleasant taste of medicament. Non‐compliance can lead to worsening of diseased condition. Numbers of taste masking technologies have been used to address the problem of patient compliance. Use of sweeteners, amino acids and flavoring agents alone are often inadequate in masking the taste of highly bitter drugs. Coating is more efficient technology for aggressively bitter drugs even though coating imperfections, if present, reduce the efficiency of the technique In Ion exchange resin (IER) method weak cation exchange or weak anion exchange resins are used for taste masking, depending on the nature of drug. The nature of the drug resin complex formed is such that the average pH of 6.7 and contain concentration of about 40meq/L in the saliva are not able to break the drug resin complex but it is weak enough to break down by hydrochloric acid present in the stomach. Thus the drug resin complex is absolutely tasteless with no after taste, and at the same time, its bioavailability is not affected. Children under the age of 8 are typically prescribed liquid medications because of smaller structure of a child's esophagus.
Authors and Affiliations
K. P Kumar, Debjit Bhowmik, Sweta Srivastava, Shravan Paswan, A. S Dutta
Keywords
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