TASTE MASKING BY HOT MELT EXTRUSION WITHOUT LOSS OF BIOAVAILABILITY FOR PEDIATRICS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2019, Vol 11, Issue 7
Abstract
Objective: The aim of present work was to develop a platform technology for the pediatric dosage form to mask the bitter taste of Furosemide (FUR) and prepare a flexible solid oral dosage form. Methods: Excipient compatibility study was carried out by using Fourier-transform infrared spectroscopy (FTIR). Taste masking was done by hot melt extrusion (HME) technology. Eudragit EPO and Soluplus were used as a taste masking and solubilizing polymers respectively. The prepared solid dispersion and tablets were evaluated for their physicochemical parameters such as hardness, friability, disintegration, in vitro drug release. Results: Experimental data revealed that physical integrity, brittleness of granules, conversion of a drug in amorphous form was improved by combining Eudragit EPO with Soluplus. Plasticizer helped to complete HME at 80 °C. Less than 10% drug release in pH 6.8 medium revealed that release would be extremely limited in the saliva and thus avoiding bitterness. Animal study data revealed that bioavailability has been increased by 30%. Differential scanning calorimetry (DSC) and x-ray diffraction (XRD) tests confirmed the existence of molecularly dispersed drug. Fourier-transform infrared spectroscopy (FTIR) confirmed the unchanged functional groups of FUR after HME processing. Conclusion: Proposed platform technology masked the bitter taste and enhanced the bioavailability of FUR in D: P ratio of 1:2.
Authors and Affiliations
Dhananjay M. , Pravin C. , Smita M.
Keywords
Related Articles
- EP ID EP593428
- DOI 10.22159/ijpps.2019v11i7.33493
- Views 84
- Downloads 0
EXPERIMENTAL EVIDENCES FOR THE PROMISING HERAPEUTIC ROLE OF VITIS VINIFERA SEED EXTRACT AGAINST NONALCOHOLIC STEATOHEPATITIS
Objective: The present study was planned to investigate the possible therapeutic effect of methanolic extract of Vitis vinifera seeds on high fat diet-induced nonalcoholic steatohepatitis (NASH) in forty adult female Wis...
ANTIPYRETIC ACTIVITY OF ETHANOLIC EXTRACT OF LEAF AND BARK OF DIOSPYROS VIRGINIANA IN YEAST INDUCED PYREXIA
Objective: To evaluate the antipyretic effect of the ethanolic extract of leaf and bark of Diospyros virginiana Linn against brewer yeast induced pyrexia model in albino rats of both sexes was investigated.Methods: The P...
ANTI-TYROSINASE AND CYTOTOXICITY ACTIVITIES OF CURCUMIN-METAL COMPLEXES
Objective: The objective of this study is investigating the potential of curcumin metal complexes in pharmaceutical and cosmetic products.Methods: Curcumin was complexed with five divalent transition metals (Zn(II), Cu(I...
IN SILICO PEPTIDE BASED VACCINE DESIGN AGAINST NON-STRUCTURAL PROTEIN 5 OF HEPATITIS C VIRUS
Objective: Hepatitis C virus (HCV) is the cause of hepatitis C in human. A hepatitis C infection does not show any noticeable symptoms in the very early stages of the infection, but a chronic infection can ultimately lea...
IN-SILICO DESIGN, SYNTHESIS AND IN VITRO ANTITUBERCULAR ACTIVITY OF NOVEL 1, 2, 4 - TRIAZOLE DERIVATIVES
Objective: To design, synthesize and in vitro anti tubercular evaluation of some new 1,2,4–triazole derivatives.Methods: Novel 1,2,4–triazole derivatives were designed by using various softwares like ACD Lab Chemsket...