Taurine prevents ethanol-induced alterations in lipids and ATPases in rat tissues.
Journal Title: Pharmacological Reports - Year 2005, Vol 57, Issue 5
Abstract
The study investigates the cytoprotective effect of taurine on ethanol-induced alterations in lipids and enzymes involved in ion-transport in rat tissues. Male albino rats were divided into 4 groups (n = 8) and maintained for 28 days as follows: control group, ethanol (6 g/kg/day) group, ethanol plus taurine (10 g/kg diet/day) group and control plus taurine group. Ethanol administration caused significant increases in the lipids in plasma and tissues, such as liver, kidney and brain, together with reductions in the activities of ATPases in tissues as compared to control animals. Histological studies revealed lipid accumulation and inflammatory cell infiltrates in the liver and kidney while edematous changes were observed in the brain. Simultaneous administration of taurine along with alcohol attenuated the rise in lipid levels and normalized ATPase activities. Histological changes were alleviated on treatment with taurine. The study suggests a bioprotective effect of taurine in ethanol intoxication.
Authors and Affiliations
Gullapalli Pushpakiran, Karthikeyan Mahalakshmi, Periyasamy Viswanathan, Carani Anuradha
Keywords
Related Articles
- EP ID EP118265
- DOI -
- Views 112
- Downloads 0
Neuroprotective effects of MTEP, a selective mGluR5 antagonists and neuropeptide Y on the kainate-induced toxicity in primary neuronal cultures.
The majority of studies on neuroprotection tested potentially protective compounds given before, simultaneously or shortly after damage. Such procedures are greatly different from the situation faced in clinical practice...
Zinc prevents hematological and biochemical alterations induced by static magnetic field in rats.
The present study was undertaken in order to investigate the effect of subchronic exposure of rats to static magnetic field (SMF) and/or zinc treatment on the selected hematological and biochemical parameters. Metallothi...
L-carnitine inhibits ethanol-induced gastric mucosal injury in rats.
L-carnitine is a quaternary amine that is essential for the normal oxidation of long-chain fatty acids by mitochondria. It is known that L-carnitine and its derivatives prevent the formation of reactive oxygen species, s...
Involvement of spinal PKA/CREB signaling pathway in the development of bone cancer pain.
Background: It has been shown that spinal PKA/CREB signaling pathway is involved in neuropathic and inflammatory pain, but its effects on bone cancer pain have not previously been investigated. The aim of this study was...
Influence of bupropion and calcium channel antagonists on the nicotine-induced memory-related response of mice in the elevated plus maze.
In this study, we investigated the effects of acute administration of nicotine on memory-related behavior in mice using the elevated plus maze test. In this test, the time necessary for mice to move from the open arm to...