Tc99m-Sestamibi Dosimetry in Myocardial Perfusion Imaging
Journal Title: American journal of Engineering Research - Year 2018, Vol 7, Issue 3
Abstract
This paper addressed myocardial perfusion imaging providing a spatial dosimetric investigation of the 99mTc-radiopharmaceutical dose distribution at the myocardium. Radiological data manipulation was performed in order to create a computational voxel model of the heart. A set of images obtained by thoracic angiotomography and abdominal aorta was set up providing anatomic and functional information for heart modeling in SISCODES code. A homogeneous distribution of 99mTc was assumed into the cardiac muscle. Simulations of the transport of particles through the voxels and the interaction with the heart tissues were performed on the MCNP – Monte Carlo Code. The spatial dose distribution in the heart model is displayed as well as the dose versus volume histogram of the heart muscle. Conclusions: The present computational tools can generate spatial doses distribution in myocardial perfusion imaging. Specially, the dosimetry performed elucidates imparted dose distribution in the myocardial muscle per unit of injected 99m Tc activity, which can contribute to future deterministic effect investigations.
Authors and Affiliations
Janine Muniz Toledo, Bruno Machado Trindade, Tarcísio Pr. Campos
Keywords
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