Te Management of Non-Invasive Bladder Tumours with Doxorubicin Intravesical Instillation after Transurethral Resection
Journal Title: Sultan Qaboos University Medical Journal - Year 2009, Vol 9, Issue 1
Abstract
Evaluation of the intravesical instillation of doxorubicin for its effect on disease recurrence for patients with non-invasive bladder tumour. Methods: Te study was performed at Al Assad University Hospital in Lattakia, Syria and included patients with non-invasive bladder tumours who were managed with transurethral resection and induction and maintenance therapy with intravesical doxorubicin. Tey were followed up by cystoscopy every 3 months for 2 years and every 6 months thereafter with special emphasis on recurrence rates. Results: Te study included 85 patients with non-invasive bladder tumours: 23 with non-invasive papillary carcinoma (Stage Ta), 62 with tumour invading subepithelial connective tissue (Stage T). Twelve patients had well differentiated tumours (Grade ), 48 had moderately differentiated (Grade 2), 25 had poorly differentiated (Grade 3) tumours. Te total recurrence rate was 23%. Te rates of recurrence were 56% in Grade 3 and 0% in Grade . Te recurrence rate was 4% in patients with large tumours versus 7% in those with small tumours; 44% in those with multiple tumours compared to 8% in those with solitary tumours; 30% of Stage Ta tumours recurred and 2% of Stage T tumours. Conclusion: In short term follow-up, our rate of recurrence was 23%. Adjuvant intravesical doxorubicin was shown to reduce the recurrence of superficial bladder cancer. Tumour grade, size and number were shown to be prognostic factors for recurrence.
Authors and Affiliations
Musa I Al-Gallab| Division of Urology, Department of Surgery, Al Assad University Hospital, Faculty of Medicine, Tishreen University, Lattakia, Syria, Louai A Naddaf| Division of Urology, Department of Surgery, Al Assad University Hospital, Faculty of Medicine, Tishreen University, Lattakia, Syria, Mohamad R Kanan| Division of Urology, Department of Surgery, Al Assad University Hospital, Faculty of Medicine, Tishreen University, Lattakia, Syria
Keywords
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