Telmisartan quality control by validation of UV-spectrophotometric method
Journal Title: International Journal of Innovative Research in Medical Science - Year 2016, Vol 1, Issue 4
Abstract
The aim of current study was to validate spectrophotometric method with UV-detection for identification and determination of Telmisartan in 99.8 % ethanol in respect of analytical parameters: selectivity, linearity, limit of detection (LOD), limit of quantification (LOQ), accuracy and precision (repeatability). For Telmisartan in 99.8 % еthanol at max = 298 nm for A1%1cm and the obtained results for А 0.2 and А 0.2 are: 1) А 0.2: at 3.10–6 g/ml 1.25.10–5 g/ml; A1%1cm: 725 823; : 37347 42335 2) А 0.2: at 2.5.10–7 g/ml 1.10–6 g/ml; A1%1cm: 1201 1567; : 61816 80651 Analytical parameter accuracy is represented by the degree of recovery, which in the corresponding confidence possibility suit the confidence interval: R СТ60: 100.31 % 102.05 %; R СТ80: 99.22 % 103.18 %; R СТ100 : 93.58 % 101.9 %. For precision is proved that all results for the quantities correspond to the relevant confidence interval: СТ60: 60.31 mg 60.77 mg; СТ80: 79.82 mg 82.18 mg; СТ100: 94.22 mg 101.58 mg.
Authors and Affiliations
Dobrina Tsvetkova, Danka Obreshkova, Stefka Ivanova, Vladimir Yankov, Peter Atanasov, Bozhidarka Hadjieva
Keywords
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