Tenofovir Disoproxil Fumarate Treatment for Pediatric Patients with Perinatally Acquired Chronic Hepatitis B
Journal Title: Gastro - Open Journal - Year 2015, Vol 1, Issue 4
Abstract
Objectives: Infection with Hepatitis B Virus (HBV) is an important cause of chronic liver disease in children. Perinatal transmission accounts for the majority of infections. We examined the effects of Tenofovir Disoproxil Fumarate (TDF) on pediatric patients with perinatally acquired Chronic Hepatitis B (CHB). Methods: We retrospectively analyzed the data on pediatric patients with perinatally acquired CHB treated with TDF over a 72-week period. Results: 55 cases were analyzed of which 26 were treated. Fourteen (54%) had immune active hepatitis and 12(46%) were in the immune tolerant phase. In both groups, no difference in inflammation or fibrosis was found on baseline liver biopsy. Mean HBV DNA level at baseline was 9 log10 copies/mL. Levels declined to 5.9 log10 copies/mL at 40 weeks of therapy and were undetectable in 19/26(73%) of the patients by week 72. Alanine aminotransferase (ALT) levels normalized by 32 weeks in the immune active hepatitis group. No breakthrough elevations were seen in either group. Overall, 11(42%) and 9(35%) of the patients had Hepatitis B e antigen (HBeAg) clearance and Hepatitis B e antibody (anti-HBe) seroconversion respectively by 72 weeks of treatment. Conclusion: TDF is an effective therapy in pediatric patients with perinatally acquired CHB in both immune active hepatitis and immune tolerant phase patients. Response to treatment did not seem to be affected by baseline ALT levels and liver histopathology findings.
Authors and Affiliations
Ricardo A. Arbizu
Keywords
Related Articles
- EP ID EP555808
- DOI 10.17140/GOJ-1-116
- Views 147
- Downloads 0
Non-alcoholic Fatty Liver Disease and the Gut Microbiota: Exploring the Connection
As the gut microbiota continues to be implicated in an increasing number of disease processes, a plethora of new literature surrounding its complexity and role in the maintenance of intestinal homeostasis has become avai...
Management of Inflammatory Bowel Diseases in Jehovah’s Witness
Background: Treatment of Inflammatory Bowel Disease (IBD) patients who are known to be Jehovah’s Witness (JW) can be a unique challenge. JW accept most available medical treatments, but may not accept blood transfusions...
The Histamine H4 Receptor: A Novel Target for Safe Anti-inflammatory Drugs?
The functional role of histamine H4 receptors (H4Rs) in the Gastrointestinal (GI) tract is reviewed, with particular reference to their involvement in the regulation of gastric mucosal defense and inflammation. H4Rs have...
The Role of Energy Metabolism in Driving Disease Progression in Inflammatory, Hypoxic and Angiogenic Microenvironments
Cellular metabolism plays a crucial role in primed inflammatory, hypoxic and angiogenic microenvironments by supporting disease progression in a range of disease entities. To adapt to fluctuating stress-induced microenvi...
Analysis of the Intracellular Zinc in HCV Replicon
Aim: In patients with chronic liver injury, metabolic disturbance of zinc was frequently observed and Hepatitis C virus (HCV) replication is crucially involved with zinc metabolism. In vitro HCV replication system, HCV r...