TERATOGENIC EFFECT OF AQUEOUS LEAF EXTRACT OF ASPILIA AFRICANA ON FRONTAL CORTEX OF ALBINO WISTAR RATS
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2017, Vol 4, Issue 9
Abstract
Aspilia Africana is one of the major herbs being used by many Nigerians to treat many ailment such as; wound healing, stoppage of bleeding, cough, gonorrhoea, feverish headache, stomach troubles and also help in easy delivery and lactation. This study was to examine the teratogenicity of aqueous leaf extract of Aspilia Africana on frontal cortex of foetal wistar rats. Twenty adult female rats weighing between 190 - 205g were used for this study. The rats were divided into four groups labelled control, low dose, medium dose and high dose, with each consisting of five rats. Pregnancy was induced by caging the female rats with sexually matured males. The presence of vaginal plug and tail structures in the vaginal smear the following morning confirmed coitus and was regarded as day zero (0) of pregnancy. Control group was given distilled water. Low dose, medium dose and high dose groups received 750mg, 1000mg and 1250mg of aqueous leaf extract of Aspilia Africana per kilogram body weight orally with the aid of orogastric tube respectively on days 7-11 of gestation. On the day 20 of gestation, the rats were sacrificed and the foetal brain was fixed in formal saline and later processed for histological studies. Histological observations of the frontal cortex showed hyperplasia and hypertrophy especially in the subventricular and ventricular layers of the low dose. Distortion of cortical, intermediate and subventricular layers of the medium dose group; and complete distortion of the layers of the frontal cortex in the high dose group characterised by numerous vacuolations and cellular degenerations. Blood vessels appeared tiny and almost absent in all the treated groups. The result suggest that aqueous leaf extract of Aspilia Africana may be teratogenic to the developing frontal cortex of wistar rats and is dose dependent.
Authors and Affiliations
Dr. Eluwa Mokutima Amarachi
Keywords
Related Articles
- EP ID EP630783
- DOI -
- Views 195
- Downloads 0
MONITORING OF PESTICIDES CHRONIC TOXICITY AMONG EXPOSED WORKERS BY USING EFFECT BIOMARKERS
Background: Workers who regularly use pesticides at increasing risk of pesticides toxicity. Monitoring of pesticides chronic toxicity is necessary to prevent long term health hazards. This review aimed to compare the val...
DETECTION OF HELICOBACTER PYLORI IN MIDDLE EAR CLEFT AND ITS POSSIBLE ROLE IN CHRONIC SUPPURATIVE OTITIS MEDIA
Aim of the work: considering the close relationship between GERD and tubotympanic disorders, the presence of helicobacter pylori in middle ear cleft and its possible role in pathogenesis of CSOM has to be investigated. P...
MACRO- AND MICROMORPHOLOGICAL STUDY OF DAUCUS CAPILLIFOLIUS GILLI CULTIVATED IN EGYPT
Macro- and micromorphological study of the leaf, stem, root, fruit and inflorescence of Daucus capillifolius Gilli was carried out with the aim of finding the characteristic features of these plant organs in both entire...
ANALGESIC PRESCRIBING PATTERN IN AN OUTPATIENT DEPARTMENT OF A TERTIARY HOSPITAL IN NORTH EAST NIGERIA
Background: Pain is a frequently encountered clinical condition and one of the common reasons for seeking medical care. It has the potential to negatively affect physical activities and quality of life. Relief from pain...
CLINICAL AND IMMUNOLOGICAL FEATURES OF PATIENTS WITH CHD ASSOCIATED WITH TNF-A
The study included 101 patients with coronary heart disease aged from 34 to 76 years (56.9 ± 0.9), of them 64.4% were men and 35.6% - women. We have shown the role of TNF-α gene (-308G> A) in the development of CHD-allel...