Teratogenic Effect of Lamotrigine on Developing Liver of Swiss Albino Mice
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 1
Abstract
The aim of present study was to observe the noxious effect of Lamotrigine (LTG) in growing liver of mice .The pregnant mice (20-25 g) were treated orally with LTG during organogenesis period i.e. 7th - 9th day of gestation. The treated group received 0.3 ml (60 mg/kg body wt) of stock solution of LTG, whereas the same volume of distilled water was given to control mice via same route. The foetuses of both control and treated group were collected on 18th day of gestation and kept in 10 % formalin for fixation. After 48 hours of fixation, liver were taken out from foetuses and observed for gross anomaly, if any and then photographed. Finally, liver of both groups were processed for histological study. On macroscopic examination, the treated liver showed increase in weight and haemorrhagic spots especially on their lateral and inferior surfaces. On microscopic examination the treated group of liver showed loss of normal architecture of hepatic cords, oedematous spaces in hepatic lobules, dilated sinusoids and central vein with destruction of their lining endothelium. The present study revealed that the lamotrigine causes noxious effect on growing liver, therefore its use in pregnant women may be advised by experts working in the field.
Authors and Affiliations
Sharda Singh, S. K. Pandey, K. N. Dwivedi, Shweta Singh
Keywords
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- EP ID EP588764
- DOI 10.9790/0853-16010298101
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