Teratogenicity of Gabapentin in Mice
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 12
Abstract
Introduction: Present work aims to study and elucidate the safety profile of the antiepileptic doses of gabapentin during pregnancy, and to evaluate if any gabapentin induced murine fetotoxicity at different dose levels. Methods: A total of 60 pregnant mice divided into a total of 12 groups, of 5 mice each were exposed to gabapentin in 4 different doses of 0 (control), or 113, 226, or 452 mg/kg body weight per day, at 3 different gestational stages including early gestation (1-6 day), mid gestation (7-12 day), and late gestation (13-17 day). The pregnant mice were euthanatized on day 18 of gestation, and foetuses were examined for teratogenic manifestations. Brains were dissected out and examined for gross changes, malformations, histological changes, and quantitative protein estimation. Results: Foetal resorptions were observed in all treated groups with gabapentin administration at early gestation (1-6 day), and mid gestation (7-12 day); on the other hand, growth retardation along with stunting in size of live foetuses were observed in all the mid gestation (7-12 day), and late gestation (13-17 day) treated groups. Various gross malformations were observed with all the three doses (113, 226, and 452 mg/kg body weight per day) when with gabapentin was administered at mid gestation (7-12 day). Same trends were confirmed by gross and microscopic examination of brains along with quantitative protein estimation. Conclusion: Gabapentin should not be prescribed in pregnancy, as no therapeutic dose of gabapentin is safe during pregnancy as far as the foetal risk is concerned
Authors and Affiliations
Dr Md. Abu Nasar
Keywords
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